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A Highly Soluble Matrix Metalloproteinase-9 Inhibitor for Potential Treatment of Dry Eye Syndrome
- Source :
- Basic & Clinical Pharmacology & Toxicology; Vol
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Dry eye syndrome (DES) or keratoconjunctivitis sicca is an eye disease caused by the chronic lack of lubrication and moisture of the eye. The pathogenesis of DES involves the over-expression and over-activity of corneal Matrix Metalloproteinase 9 (MMP-9). We propose herein a new, non-symptomatic approach for the treatment of DES based on the inhibition of MMP-9 by a new highly soluble molecule, designed as PES_103 that has been shown to inhibit MMP-9 both in vitro and in vivo. The efficacy of PES_103 in vivo and the potential benefits of this treatment in restoring tear production were studied in this work using an animal model of reduced lacrimation. PES_103 did not show any significant corneal toxicity.
- Subjects :
- Pathology
medicine.medical_specialty
genetic structures
Eye disease
Matrix metalloproteinase
Pharmacology
Toxicology
Pathogenesis
03 medical and health sciences
0302 clinical medicine
Animal model
In vivo
matrix metalloproteinases
Enzyme Inhibitors
medicine
KERATOCONJUNCTIVITIS SICCA
030304 developmental biology
0303 health sciences
Chemistry
Matrix metalloproteinase 9
General Medicine
medicine.disease
eye diseases
In vitro
3. Good health
030221 ophthalmology & optometry
sense organs
Subjects
Details
- ISSN :
- 17427835
- Database :
- OpenAIRE
- Journal :
- Basic & Clinical Pharmacology & Toxicology
- Accession number :
- edsair.doi.dedup.....81cec334c6f989131d2f692b47e4b378
- Full Text :
- https://doi.org/10.1111/j.1742-7843.2012.00896.x