Back to Search Start Over

Apocynin-Tandospirone Derivatives Suppress Methamphetamine-Induced Hyperlocomotion in Rats with Neonatal Exposure to Dizocilpine

Authors :
Takashi Uehara
Masayoshi Kurachi
Takashi Kondo
Hitoshi Abe
Hiroko Itoh
Tomiki Sumiyoshi
Michio Suzuki
Source :
Journal of Personalized Medicine; Volume 12; Issue 3; Pages: 366
Publication Year :
2022

Abstract

Accumulating evidence implicates oxidative stress as a potential pathophysiological mechanism of schizophrenia. Accordingly, we synthesized new chemicals using apocynin and tandospirone as lead compounds (A-2, A-3 and A-4). These novel compounds decreased reactive oxygen species (ROS) concentrations in vitro and reversed decreases in glutathione levels in the medial prefrontal cortex of rats transiently exposed to MK-801, an N-methyl-d-aspartate receptor antagonist, in the neonatal period. To determine whether A-2, A-3 and A-4 show behavioral effects associated with antipsychotic properties, the effects of these compounds on methamphetamine (MAP)-induced locomotor and vertical activity were examined in the model rats. A-2 and A-3, administered for 14 days around the puberty period, ameliorated MAP-induced hyperlocomotion in MK-801-treated rats in the post-puberty period, while A-4 suppressed MAP-induced vertical activity. These findings indicate that apocynin-tandospirone derivatives present anti-dopaminergic effects and may alleviate psychotic symptoms of schizophrenia.

Details

ISSN :
20754426
Volume :
12
Issue :
3
Database :
OpenAIRE
Journal :
Journal of personalized medicine
Accession number :
edsair.doi.dedup.....81cfac523012e9c943bc7eeaa197ee87