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Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure
- Source :
- PLoS ONE, Vol 6, Iss 9, p e24272 (2011), PLoS ONE
- Publication Year :
- 2011
- Publisher :
- Public Library of Science (PLoS), 2011.
-
Abstract
- Animal studies suggest that regulatory T (T(reg)) cells play a beneficial role in ventricular remodeling and our previous data have demonstrated defects of T(reg) cells in patients with chronic heart failure (CHF). However, the mechanisms behind T(reg-)cell defects remained unknown. We here sought to elucidate the mechanism of T(reg-)cell defects in CHF patients.We performed flow cytometry analysis and demonstrated reduced numbers of peripheral blood CD4(+)CD25(+)FOXP3(+)CD45RO(-)CD45RA(+) naïve T(reg) (nT(reg)) cells and CD4(+)CD25(+)FOXP3(+)CD45RO(+)CD45RA(-) memory T(reg) (mT(reg)) cells in CHF patients as compared with non-CHF controls. Moreover, the nT(reg)/mT(reg) ratio (p
- Subjects :
- CD4-Positive T-Lymphocytes
Male
Anatomy and Physiology
Cell
lcsh:Medicine
Apoptosis
030204 cardiovascular system & hematology
Cardiovascular
T-Lymphocytes, Regulatory
0302 clinical medicine
immune system diseases
hemic and lymphatic diseases
Molecular Cell Biology
Homeostasis
lcsh:Science
Cells, Cultured
0303 health sciences
Multidisciplinary
Cell Death
T Cells
Forkhead Transcription Factors
hemic and immune systems
Middle Aged
Flow Cytometry
3. Good health
medicine.anatomical_structure
Medicine
Female
Animal studies
medicine.drug
circulatory and respiratory physiology
Research Article
Interleukin 2
Adult
Fas Ligand Protein
Regulatory T cell
Immune Cells
Immunology
chemical and pharmacologic phenomena
Thymus Gland
Real-Time Polymerase Chain Reaction
03 medical and health sciences
Immune system
medicine
Humans
cardiovascular diseases
Ventricular remodeling
Biology
030304 developmental biology
Heart Failure
business.industry
lcsh:R
Interleukin-2 Receptor alpha Subunit
medicine.disease
Heart failure
Chronic Disease
Interleukin-2
Clinical Immunology
lcsh:Q
business
Physiological Processes
Cytometry
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 6
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....81d08b525fe9c0f382c788cedb2cefd2