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Highly Conserved Protective Epitopes on Influenza B Viruses
- Source :
- Science, 337(6100), 1343-1348. American Association for the Advancement of Science
- Publication Year :
- 2012
-
Abstract
- Influenza Antibodies, Part B With its ability to reassort in animal hosts like pigs and birds, and to cause pandemics, influenza A viruses are often in the spotlight. However, a substantial portion of the annual flu burden is also the result of influenza B virus, which is a single influenza type that is characterized by two antigenically and genetically distinct lineages. Dreyfus et al. (p. 1343 , published online 9 August) identify three monoclonal human antibodies that are able to protect against lethal infection with both lineages of influenza B virus in mice. Two antibodies, which bind to distinct regions of the viral hemagluttinin (HA) molecule, neutralize multiple strains from both lineages of influenza B virus, whereas the third antibody binds to the stem region of HA and is able to neutralize both influenza A and B strains. The structural data from these antibodies bound to HA, together with already known antibodies targeting influenza A, may provide clues for designing a universal vaccine to protect against both influenza virus types.
- Subjects :
- medicine.drug_class
Protein Conformation
Molecular Sequence Data
Hemagglutinin (influenza)
Hemagglutinin Glycoproteins, Influenza Virus
Biology
Universal flu vaccine
Monoclonal antibody
H5N1 genetic structure
Epitope
Antigenic drift
Article
Microbiology
Mice
Orthomyxoviridae Infections
Neutralization Tests
medicine
Animals
Humans
Amino Acid Sequence
Conserved Sequence
Multidisciplinary
Immunodominant Epitopes
Antigenic shift
virus diseases
Antibodies, Monoclonal
Virology
Antibodies, Neutralizing
Influenza B virus
Influenza Vaccines
biology.protein
Antibody
Subjects
Details
- Language :
- English
- ISSN :
- 00368075
- Database :
- OpenAIRE
- Journal :
- Science, 337(6100), 1343-1348. American Association for the Advancement of Science
- Accession number :
- edsair.doi.dedup.....81ed058a9ac64993a2c3ae641214d4f8