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Effects of Acquired Obesity on Endothelial Function in Monozygotic Twins*
- Source :
- University of Helsinki
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Objective: To determine whether acquired obesity or accompanying metabolic changes such as adiponectin deficiency, insulin resistance, dyslipidemia, or visceral fat are associated, independent of genetic influences, with endothelial dysfunction by studying young adult monozygotic (MZ) twin pairs discordant for obesity. Research Methods and Procedures: Nine obesity-discordant (intra-pair difference in BMI, 3.8 to 10.1 kg/m2) and nine concordant (0 to 2.3 kg/m2) 24- to 27-year-old MZ twin pairs were identified from a population-based FinnTwin16-sample. Endothelial function was measured by blood flow responses to intrabrachial infusions of an endothelium-dependent (acetylcholine) and an endothelium-independent (sodium nitroprusside) vasodilator. Whole body insulin sensitivity was measured using the euglycemic insulin clamp technique, and forearm and body composition were measured with magnetic resonance imaging and DXA. In addition, serum levels of adiponectin, high-sensitivity C-reactive protein, and lipids were determined. Results: The heavier co-twins of the discordant pairs had significantly lower whole body insulin sensitivity than the leaner co-twins. Blood flows/muscle volume during infusions of acetylcholine and sodium nitroprusside were not altered by obesity. However, intra-pair differences in serum adiponectin, intra-abdominal fat, and C-reactive protein were significantly correlated with those in endothelial function. Only the relationship between intra-pair differences in adiponectin and endothelial function persisted in multiple linear regression analysis. Obesity-concordant co-twins had comparable insulin sensitivity and endothelial function. Discussion: In young adult MZ twins discordant for obesity, acquired adiponectin deficiency rather than obesity per se is an independent correlate of endothelial dysfunction.
- Subjects :
- Male
Vasodilator Agents
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
Adipose tissue
Blood Pressure
030204 cardiovascular system & hematology
Body Mass Index
0302 clinical medicine
Endocrinology
Heart Rate
Medicine
Endothelial dysfunction
0303 health sciences
education.field_of_study
Nutrition and Dietetics
Forearm
C-Reactive Protein
Cholesterol
Body Composition
Regression Analysis
Female
Adiponectin
Sodium nitroprusside
Blood Flow Velocity
medicine.drug
Adult
Nitroprusside
medicine.medical_specialty
Population
03 medical and health sciences
Insulin resistance
Internal medicine
Diseases in Twins
Humans
Obesity
education
Triglycerides
030304 developmental biology
Dose-Response Relationship, Drug
business.industry
Cholesterol, HDL
Cholesterol, LDL
Twins, Monozygotic
medicine.disease
Acetylcholine
Endothelium, Vascular
Insulin Resistance
business
Dyslipidemia
Subjects
Details
- ISSN :
- 1930739X and 19307381
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Obesity
- Accession number :
- edsair.doi.dedup.....821c903f5600b8b75526a712f56cad4c