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Preclinical evaluation of alternative pharmaceutical delivery vehicles for paclitaxel
- Source :
- Anti-Cancer Drugs, 13, 767-775. Lippincott Williams & Wilkins
- Publication Year :
- 2002
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2002.
-
Abstract
- New solubilizers, including Sorporol 230, Sorporol 120Ex, Aceporol 345-T, Aceporol 460 and Riciporol 335, as potential new delivery vehicles for paclitaxel were investigated, since recent studies have shown that the paclitaxel delivery vehicle Cremophor EL significantly alters the pharmacokinetics of paclitaxel. Cremophor EL and Tween 80 were used as a reference. As in the case of Cremophor EL, alteration of blood distribution of paclitaxel occurred in the presence of all tested vehicles. Also, no differences in the affinity of paclitaxel for the tested solubilizers was found during equilibrium dialysis experiments. The different vehicles could be distinguished by a different rate of esterase-mediated breakdown, which was correlated with the fatty acid content of the solubilizers. The activation of the complement cascade was less pronounced for all solubilizers, except Riciporol 335, compared to Cremophor EL. The strategies presented here provide the possibility to rapidly screen future candidate delivery vehicles with optimal characteristics for use as a solubilizer in clinical formulations of paclitaxel or other poorly water-soluble drugs.
- Subjects :
- Cancer Research
Paclitaxel
In Vitro Techniques
Pharmacology
chemistry.chemical_compound
Drug Stability
Pharmacokinetics
Humans
Medicine
Distribution (pharmacology)
Pharmacology (medical)
Chromatography, High Pressure Liquid
Delivery vehicle
business.industry
Reference Standards
Antineoplastic Agents, Phytogenic
Pharmaceutical Solutions
Solubility
Oncology
chemistry
Solubilization
Indicators and Reagents
Pharmaceutical Vehicles
business
Subjects
Details
- ISSN :
- 09594973
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Anti-Cancer Drugs
- Accession number :
- edsair.doi.dedup.....822dd3b240f22be7fc14ee87c9b2094a
- Full Text :
- https://doi.org/10.1097/00001813-200208000-00012