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The effect of simvastatin treatment on behavioral parameters, cognitive performance, and hippocampal morphology in rats fed a standard or a high-fat diet
- Source :
- Behavioural pharmacology. 23(5-6)
- Publication Year :
- 2012
-
Abstract
- WOS: 000307246100013<br />PubMed ID: 22797467<br />The aim of this study was to examine the effect of simvastatin (SMV), a 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor, in rats fed with a standard or a high-fat diet (HFD) throughout the prenatal and the postnatal periods. The emotional status of the animals was evaluated by elevated plus-maze and modified forced swimming tests, whereas cognitive performance was assessed by a Morris water maze task. Morphological changes in the hippocampus were examined by design-based stereology. HFD exposure significantly increased blood serum triglycerides without altering cholesterol levels relative to the controls. After four weeks of oral SMV (5 mg/kg) administration, serum triglycerides reverted to the control level. SMV caused significant anxiolytic, antidepressant-like, and nootropic effects in animals fed the standard diet. In the HFD group, enhanced anxiety and depression, and reduced cognitive performances of animals were reversed by SMV treatment. Although a total volume estimation of the hippocampal subfields indicated no significant change among the groups, the total number of pyramidal neurons decreased significantly in animals fed the HFD; following SMV treatment, this detrimental effect was reversed. In conclusion, chronic SMV administration has significant therapeutic potential for the treatment of affective and cognitive disorders with or without altering the serum lipid profiles. Behavioural Pharmacology 23:582-592 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
- Subjects :
- Male
medicine.medical_specialty
Simvastatin
medicine.drug_class
Stereology
Neurogenesis
Morris water navigation task
Anxiety
Optic Fractionator
Diet, High-Fat
Anxiolytic
Hippocampus
Nootropic
Rats, Sprague-Dawley
chemistry.chemical_compound
Blood serum
Pregnancy
Internal medicine
Medicine
Hippocampus (mythology)
Animals
Lactation
Nootropic Agents
Pharmacology
Hypertriglyceridemia
Neurons
Morris Water Maze
Behavior, Animal
Depression
business.industry
Cholesterol
Cavalieri Volume Estimation
Maternal High-Fat Diet
Maternal Nutritional Physiological Phenomena
Antidepressive Agents
Rats
Psychiatry and Mental health
Endocrinology
Neuroprotective Agents
chemistry
Anti-Anxiety Agents
Rat
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
business
Cognition Disorders
medicine.drug
Subjects
Details
- ISSN :
- 14735849, 00030724, and 22797467
- Volume :
- 23
- Issue :
- 5-6
- Database :
- OpenAIRE
- Journal :
- Behavioural pharmacology
- Accession number :
- edsair.doi.dedup.....824debe64f5d5f91be8062094c1b4ef9