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Examining Evidence of Benefits and Risks for Pasteurizing Donor Breastmilk

Authors :
Rodney R. Dietert
Margaret E. Coleman
D. Warner North
Michele M. Stephenson
Source :
Applied Microbiology, Volume 1, Issue 3, Pages 27-425
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

An evidence map is visualized as a starting point for deliberations by trans-disciplinary stakeholders, including microbiologists with interests in the evidence and its influence on health and safety. Available evidence for microbial benefits and risks of the breastmilk ecosystem was structured as an evidence map using established risk analysis methodology. The evidence map based on the published literature and reports included the evidence basis, pro- and contra-arguments with supporting and attenuating evidence, supplemental studies on mechanisms, overall conclusions, and remaining uncertainties. The evidence basis for raw breastmilk included one benefit–risk assessment, systematic review, and systematic review/meta-analysis, and two cohort studies. The evidence basis for benefits was clear, convincing, and conclusive, with supplemental studies on plausible mechanisms attributable to biologically active raw breastmilk. Limited evidence was available to assess microbial risks associated with raw breastmilk and pasteurized donor milk. The evidence map provides transparent communication of the ‘state-of-the-science’ and uncertainties for microbial benefits and risks associated with the breastmilk microbiota to assist in deeper deliberations of the evidence with decision makers and stakeholders. The long-term aims of the evidence map are to foster deliberation, motivate additional research and analysis, and inform future evidence-based policies about pasteurizing donor breastmilk.

Details

ISSN :
26738007
Volume :
1
Database :
OpenAIRE
Journal :
Applied Microbiology
Accession number :
edsair.doi.dedup.....825a31a15759b816844b90266cc36e6c
Full Text :
https://doi.org/10.3390/applmicrobiol1030027