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Outcomes of surgical resection of gallbladder cancer in patients presenting with jaundice: A systematic review and meta-analysis
- Source :
- Journal of surgical oncology. 118(3)
- Publication Year :
- 2018
-
Abstract
- INTRODUCTION Preoperative jaundice is considered a relative contraindication to radical gallbladder cancer (GBC) resection due to poor prognosis and high postoperative morbidity. Recent reports have indicated that aggressive surgery may improve long-term survival for patients with advanced GBC who present with obstructive jaundice. The current systematic review and meta-analysis aimed to compare postoperative outcomes among jaundiced and non-jaundiced patients with resectable GBC. METHODS An electronic search was performed using several Medical Subject Headings terms: cholecyst, gallbladder, tumor, cancer, carcinoma, adenocarcinoma, neoplasia, neoplasm, jaundice, and icterus. Overall survival after surgery was the primary outcome; resectability and postoperative morbidity were the secondary outcomes. RESULTS Overall survival was shorter among patients who presented with jaundice (Hazard ratio [HR]: 2.21, 95% confidence interval [CI], 1.64-2.97; P
- Subjects :
- medicine.medical_specialty
Jaundice
03 medical and health sciences
0302 clinical medicine
medicine
Carcinoma
Hepatectomy
Humans
Radical surgery
Gallbladder cancer
Contraindication
business.industry
Gallbladder
Hazard ratio
General Medicine
Odds ratio
medicine.disease
Prognosis
Surgery
Survival Rate
medicine.anatomical_structure
Oncology
Bile Duct Neoplasms
030220 oncology & carcinogenesis
030211 gastroenterology & hepatology
Gallbladder Neoplasms
medicine.symptom
business
Subjects
Details
- ISSN :
- 10969098
- Volume :
- 118
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of surgical oncology
- Accession number :
- edsair.doi.dedup.....82738a1dd0e1e12e595ca8efe37055eb