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Engineering Venom’s Toxin-Neutralizing Antibody Fragments and Its Therapeutic Potential
- Source :
- Toxins, Toxins, MDPI, 2014, 6 (8), pp.2541-2567. ⟨10.3390/toxins6082541⟩, Toxins, Vol 6, Iss 8, Pp 2541-2567 (2014), Toxins 8 (6), 2541-2567. (2014)
- Publication Year :
- 2014
- Publisher :
- MDPI AG, 2014.
-
Abstract
- Serum therapy remains the only specific treatment against envenoming, but anti-venoms are still prepared by fragmentation of polyclonal antibodies isolated from hyper-immunized horse serum. Most of these anti-venoms are considered to be efficient, but their production is tedious, and their use may be associated with adverse effects. Recombinant antibodies and smaller functional units are now emerging as credible alternatives and constitute a source of still unexploited biomolecules capable of neutralizing venoms. This review will be a walk through the technologies that have recently been applied leading to novel antibody formats with better properties in terms of homogeneity, specific activity and possible safety.
- Subjects :
- [SDV]Life Sciences [q-bio]
Health, Toxicology and Mutagenesis
diabody
Antivenom
lcsh:Medicine
Venom
Review
snakebite
Toxicology
medicine.disease_cause
scFv
law.invention
law
antibody
anticorps recombinant
Bites and Stings
Neutralizing antibody
Immunoglobulin Fragments
0303 health sciences
Antivenins
030302 biochemistry & molecular biology
Antibodies, Monoclonal
antivenin
Recombinant Proteins
3. Good health
scorpion stings
antivenom
nanobody
serum therapy
Recombinant DNA
Antibody
sérothérapie
morsure
Biology
03 medical and health sciences
scorpion
medicine
Animals
Humans
030304 developmental biology
serpent
Venoms
Toxin
lcsh:R
piqure
Antibodies, Neutralizing
Virology
Polyclonal antibodies
Immunology
biology.protein
Subjects
Details
- ISSN :
- 20726651
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Toxins
- Accession number :
- edsair.doi.dedup.....8275de0868fe46d61e78b065a99cab68