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A first update on mapping the human genetic architecture of COVID-19
Authors :
COVID-19 Host Genetics Initiative Pathak, GA Karjalainen, J Stevens, C Neale, BM Daly, M Ganna, A Andrews, SJ Kanai, M Cordioli, M Polimanti, R Harerimana, N Pirinen, M Liao, RG Chwialkowska, K Trankiem, A Balaconis, MK Nguyen, H Solomonson, M Veerapen, K Wolford, B Roberts, G Park, D Ball, CA Coignet, M McCurdy, S Knight, S Partha, R Rhead, B Zhang, M Berkowitz, N Gaddis, M Noto, K Ruiz, L Pavlovic, M Hong, EL Rand, K Girshick, A Guturu, H Baltzell, AH Niemi, MEK Rahmouni, S Guntz, J Beguin, Y Pigazzini, S Nkambule, L Georges, M Moutschen, M Misset, B Darcis, G Guiot, J Azarzar, S Gofflot, S Claassen, S Malaise, O Huynen, P Meuris, C Thys, M Jacques, J Leonard, P Frippiat, F Giot, J-B Sauvage, A-S Frenckell, CV Belhaj, Y Lambermont, B Nakanishi, T Morrison, DR Mooser, V Richards, JB Butler-Laporte, G Forgetta, V Li, R Ghosh, B Laurent, L Belisle, A Henry, D Abdullah, T Adeleye, O Mamlouk, N Kimchi, N Afrasiabi, Z Rezk, N Vulesevic, B Bouab, M Guzman, C Petitjean, L Tselios, C Xue, X Afilalo, J Afilalo, M Oliveira, M Brenner, B Brassard, N Durand, M Schurr, E Lepage, P Ragoussis, J Auld, D Chassé, M Kaufmann, DE Lathrop, GM Adra, D Hayward, C Glessner, JT Shaw, DM Campbell, A Morris, M Hakonarson, H Porteous, DJ Below, J Richmond, A Chang, X Polikowski, H Lauren, PE Chen, H-H Wanying, Z Fawns-Ritchie, C North, K McCormick, JB Glessner, JR Gignoux, CR Wicks, SJ Crooks, K Barnes, KC Daya, M Shortt, J Rafaels, N Chavan, S Timmers, PRHJ Wilson, JF Tenesa, A Kerr, SM D’Mellow, K Shahin, D El-Sherbiny, YM von Hohenstaufen, KA Sobh, A Eltoukhy, MM Nkambul, L Elhadidy, TA Abd Elghafar, MS El-Jawhari, JJ Mohamed, AAS Elnagdy, MH Samir, A Abdel-Aziz, M Khafaga, WT El-Lawaty, WM Torky, MS El-shanshory, MR Yassen, AM Hegazy, MAF Okasha, K Eid, MA Moahmed, HS Medina-Gomez, C Ikram, MA Uitterlinden, AG Mägi, R Milani, L Metspalu, A Laisk, T Läll, K Lepamets, M Esko, T Reimann, E Naaber, P Laane, E Pesukova, J Peterson, P Kisand, K Tabri, J Allos, R Hensen, K Starkopf, J Ringmets, I Tamm, A Kallaste, A Alavere, H Metsalu, K Puusepp, M Batini, C Tobin, MD Venn, LD Lee, PH Shrine, N Williams, AT Guyatt, AL John, C Packer, RJ Ali, A Free, RC Wang, X Wain, LV Hollox, EJ Bee, CE Adams, EL Palotie, A Ripatti, S Ruotsalainen, S Kristiansson, K Koskelainen, S Perola, M Donner, K Kivinen, K Kaunisto, M Rivolta, C Bochud, P-Y Bibert, S Boillat, N Nussle, SG Albrich, W Quinodoz, M Kamdar, D Suh, N Neofytos, D Erard, V Voide, C Friolet, R Vollenweider, P Pagani, JL Oddo, M zu Bentrup, FM Conen, A Clerc, O Marchetti, O Guillet, A Guyat-Jacques, C Foucras, S Rime, M Chassot, J Jaquet, M Viollet, RM Lannepoudenx, Y Portopena, L Bochud, PY Desgranges, F Filippidis, P Guéry, B Haefliger, D Kampouri, EE Manuel, O Munting, A Papadimitriou-Olivgeris, M Regina, J Rochat-Stettler, L Suttels, V Tadini, E Tschopp, J Van Singer, M Viala, B Boillat-Blanco, N Brahier, T Hügli, O Meuwly, JY Pantet, O Gonseth Nussle, S Bochud, M D’Acremont, V Estoppey Younes, S Albrich, WC Cerny, A O’Mahony, L von Mering, C Frischknecht, M Kleger, G-R. Filipovic, M Kahlert, CR Wozniak, H Negro, TR Pugin, J Bouras, K Knapp, C Egger, T Perret, A Montillier, P di Bartolomeo, C Barda, B de Cid, R Carreras, A Moreno, V Kogevinas, M Galván-Femenía, I Blay, N Farré, X Sumoy, L Cortés, B Mercader, JM Guindo-Martinez, M Torrents, D Garcia-Aymerich, J Castaño-Vinyals, G Dobaño, C Gori, M Renieri, A Mari, F Mondelli, MU Castelli, F Vaghi, M Rusconi, S Montagnani, F Bargagli, E Franchi, F Mazzei, MA Cantarini, L Tacconi, D Feri, M Scala, R Spargi, G Nencioni, C Bandini, M Caldarelli, GP Canaccini, A Ognibene, A D’Arminio Monforte, A Girardis, M Antinori, A Francisci, D Schiaroli, E Scotton, PG Panese, S Scaggiante, R Monica, MD Capasso, M Fiorentino, G Castori, M Aucella, F Biagio, AD Masucci, L Valente, S Mandalà, M Zucchi, P Giannattasio, F Coviello, DA Mussini, C Tavecchia, L Crotti, L Rizzi, M Rovere, MTL Sarzi-Braga, S Bussotti, M Ravaglia, S Artuso, R Perrella, A Romani, D Bergomi, P Catena, E Vincenti, A Ferri, C Grassi, D Pessina, G Tumbarello, M Pietro, MD Sabrina, R Luchi, S Furini, S Dei, S Benetti, E Picchiotti, N Sanarico, M Ceri, S Pinoli, P Raimondi, F Biscarini, F Stella, A Zguro, K Capitani, K Tanfoni, M Fallerini, C Daga, S Baldassarri, M Fava, F Frullanti, E Valentino, F Doddato, G Giliberti, A Tita, R Amitrano, S Bruttini, M Croci, S Meloni, I Mencarelli, MA Rizzo, CL Pinto, AM Beligni, G Tommasi, A Sarno, LD Palmieri, M Carriero, ML Alaverdian, D Busani, S Bruno, R Vecchia, M Belli, MA Mantovani, S Ludovisi, S Quiros-Roldan, E Antoni, MD Zanella, I Siano, M Emiliozzi, A Fabbiani, M Rossetti, B Bergantini, L D’Alessandro, M Cameli, P Bennett, D Anedda, F Marcantonio, S Scolletta, S Guerrini, S Conticini, E Frediani, B Spertilli, C Donati, A Guidelli, L Corridi, M Croci, L Piacentini, P Desanctis, E Cappelli, S Verzuri, A Anemoli, V Pancrazzi, A Lorubbio, M Miraglia, FG Venturelli, S Cossarizza, A Vergori, A Gabrieli, A Riva, A Paciosi, F Andretta, F Gatti, F Parisi, SG Baratti, S Piscopo, C Russo, R Andolfo, I Iolascon, A Carella, M Merla, G Squeo, GM Raggi, P Marciano, C Perna, R Bassetti, M Sanguinetti, M Giorli, A Salerni, L Parravicini, P Menatti, E Trotta, T Coiro, G Lena, F Martinelli, E Mancarella, S Gabbi, C Maggiolo, F Ripamonti, D Bachetti, T Suardi, C Parati, G Bottà, G Domenico, PD Rancan, I Bianchi, F Colombo, R Barbieri, C Acquilini, D Andreucci, E Segala, FV Tiseo, G Falcone, M Lista, M Poscente, M Vivo, OD Petrocelli, P Guarnaccia, A Baroni, S van Heel, DA Hunt, KA Trembath, RC Huang, QQ Martin, HC Mason, D Trivedi, B Wright, J Finer, S Akhtar, S Anwar, M Arciero, E Ashraf, S Breen, G Chung, R Curtis, CJ Chowdhury, M Colligan, G Deloukas, P Durham, C Griffiths, C Hurles, M Hussain, S Islam, K Khan, A Lavery, C Lee, SH Lerner, R MacArthur, D MacLaughlin, B Martin, H Miah, S Newman, B Safa, N Tahmasebi, F Griffiths, CJ Smith, AV Boughton, AP Li, KW LeFaive, J Annis, A Niavarani, A Aliannejad, R Sharififard, B Amirsavadkouhi, A Naderpour, Z Tadi, HA Aleagha, AE Ahmadi, S Moghaddam, SBM Adamsara, A Saeedi, M Abdollahi, H Hosseini, A Chariyavilaskul, P Jantarabenjakul, W Hirankarn, N Chamnanphon, M Suttichet, TB Shotelersuk, V Pongpanich, M Phokaew, C Chetruengchai, W Putchareon, O Torvorapanit, P Puthanakit, T Suchartlikitwong, P Nilaratanakul, V Sodsai, P Brumpton, BM Hveem, K Willer, C Zhou, W Rogne, T Solligard, E Åsvold, BO Franke, L Boezen, M Deelen, P Claringbould, A Lopera, E Warmerdam, R Vonk, JM van Blokland, I Lanting, P Ori, APS Feng, Y-CA Mercader, J Weiss, ST Karlson, EW Smoller, JW Murphy, SN Meigs, JB Woolley, AE Green, RC Perez, EF Zöllner, S Wang, J Beck, A Sloofman, LG Ascolillo, S Sebra, RP Collins, BL Levy, T Buxbaum, JD Sealfon, SC Jordan, DM Thompson, RC Gettler, K Chaudhary, K Belbin, GM Preuss, M Hoggart, C Choi, S Underwood, SJ Salib, I Britvan, B Keller, K Tang, L Peruggia, M Hiester, LL Niblo, K Aksentijevich, A Labkowsky, A Karp, A Zlatopolsky, M Zyndorf, M Charney, AW Beckmann, ND Schadt, EE Abul-Husn, NS Cho, JH Itan, Y Kenny, EE Loos, RJF Nadkarni, GN Do, R O’Reilly, P Huckins, LM Ferreira, MAR Abecasis, GR Leader, JB Cantor, MN Justice, AE Carey, DJ Chittoor, G Josyula, NS Kosmicki, JA Horowitz, JE Baras, A Gass, MC Yadav, A Mirshahi, T Hottenga, JJ Bartels, M de geus, EEJC Nivard, MMG Verma, A Ritchie, MD Rader, D Li, B Verma, SS Lucas, A Bradford, Y Abedalthagafi, M Alaamery, M Alshareef, A Sawaji, M Massadeh, S AlMalik, A Alqahtani, S Baraka, D Harthi, FA Alsolm, E Safieh, LA Alowayn, AM Alqubaishi, F Mutairi, AA Mangul, S Almutairi, M Aljawini, N Albesher, N Arabi, YM Mahmoud, ES Khattab, AK Halawani, RT Alahmadey, ZZ Albakri, JK Felemban, WA Suliman, BA Hasanato, R Al-Awdah, L Alghamdi, J AlZahrani, D AlJohani, S Al-Afghani, H AlDhawi, N AlBardis, H Alkwai, S Alswailm, M Almalki, F Albeladi, M Almohammed, I Barhoush, E Albader, A Alotaibi, S Alghamdi, B Jung, J fawzy, MS Alrashed, M Zeberg, H Frithiof, R Hultström, M Lipcsey, M Tardif, N Rooyackers, O Grip, J Maricic, T Helgeland, Ø Magnus, P Trogstad, L-IS Lee, Y Harris, JR Mangino, M Spector, TD Emma, D Moutsianas, L Caulfield, MJ Scott, RH Kousathanas, A Pasko, D Walker, S Stuckey, A Odhams, CA Rhodes, D Fowler, T Rendon, A Chan, G Arumugam, P Karczewski, KJ Martin, AR Wilson, DJ Spencer, CCA Crook, DW Wyllie, DH O’Connell, AM Atkinson, EG Tsuo, K Baya, N Turley, P Gupta, R Walters, RK Palmer, DS Sarma, G Cheng, N Lu, W Churchhouse, C Goldstein, JI King, D Seed, C Daly, MJ Finucane, H Bryant, S Satterstrom, FK Band, G Earle, SG Lin, S-K Arning, N Koelling, N Armstrong, J Rudkin, JK Callier, S Cusick, C Soranzo, N Zhao, JH Danesh, J Angelantonio, ED Butterworth, AS Sun, YV Huffman, JE Cho, K O’Donnell, CJ Tsao, P Gaziano, JM Peloso, G Ho, Y-L Smieszek, SP Polymeropoulos, C Polymeropoulos, V Polymeropoulos, MH Przychodzen, BP Fernandez-Cadenas, I Planas, AM Perez-Tur, J Llucià-Carol, L Cullell, N Muiño, E Cárcel-Márquez, J DeDiego, ML Iglesias, LL Soriano, A Rico, V Agüero, D Bedini, JL Lozano, F Domingo, C Robles, V Ruiz-Jaén, F Márquez, L Gomez, J Coto, E Albaiceta, GM García-Clemente, M Dalmau, D Arranz, MJ Dietl, B Serra-Llovich, A Soler, P Colobrán, R Martín-Nalda, A Martínez, AP Bernardo, D Rojo, S Fiz-López, A Arribas, E de la Cal-Sabater, P Segura, T González-Villa, E Serrano-Heras, G Martí-Fàbregas, J Jiménez-Xarrié, E de Felipe Mimbrera, A Masjuan, J García-Madrona, S Domínguez-Mayoral, A Villalonga, JM Menéndez-Valladares, P Chasman, DI Sesso, HD Manson, JE Buring, JE Ridker, PM Franco, G Davis, L Lee, S Priest, J Sankaran, VG van Heel, D Biesecker, L Kerchberger, VE Baillie, JK Pathak, Gita A. Karjalainen, Juha Stevens, Christine Neale, Benjamin M. Daly, Mark Ganna, Andrea Andrews, Shea J. Kanai, Masahiro Cordioli, Mattia Polimanti, Renato Harerimana, Nadia Pirinen, Matti Liao, Rachel G. Chwialkowska, Karolina Trankiem, Amy Balaconis, Mary K. Nguyen, Huy Solomonson, Matthew Veerapen, Kumar Wolford, Brooke Roberts, Genevieve Park, Danny Ball, Catherine A. Coignet, Marie McCurdy, Shannon Knight, Spencer Partha, Raghavendran Rhead, Brooke Zhang, Miao Berkowitz, Nathan Gaddis, Michael Noto, Keith Ruiz, Luong Pavlovic, Milo Hong, Eurie L. Rand, Kristin Girshick, Ahna Guturu, Harendra Baltzell, Asher Haug Niemi, Mari E. K. Rahmouni, Souad Guntz, Julien Beguin, Yve Pigazzini, Sara Nkambule, Lindokuhle Georges, Michel Moutschen, Michel Misset, Benoit Darcis, Gille Guiot, Julien Azarzar, Samira Gofflot, Stéphanie Claassen, Sabine Malaise, Olivier Huynen, Pascale Meuris, Christelle Thys, Marie Jacques, Jessica Léonard, Philippe Frippiat, Frederic Giot, Jean-Baptiste Sauvage, Anne-Sophie Frenckell, Christian Von Belhaj, Yasmine Lambermont, Bernard Nakanishi, Tomoko Morrison, David R. Mooser, Vincent Richards, J. Brent Butler-Laporte, Guillaume Forgetta, Vincenzo Li, Rui Ghosh, Biswarup Laurent, Laetitia Belisle, Alexandre Henry, Danielle Abdullah, Tala Adeleye, Olumide Mamlouk, Noor Kimchi, Nofar Afrasiabi, Zaman Rezk, Nardin Vulesevic, Branka Bouab, Meriem Guzman, Charlotte Petitjean, Loui Tselios, Chri Xue, Xiaoqing Afilalo, Jonathan Afilalo, Marc Oliveira, Maureen Brenner, Bluma Brassard, Nathalie Durand, Madeleine Schurr, Erwin Lepage, Pierre Ragoussis, Jianni Auld, Daniel Chassé, Michaël Kaufmann, Daniel E. Lathrop, G. Mark Adra, Darin Hayward, Caroline Glessner, Joseph T. Shaw, Douglas M. Campbell, Archie Morris, Marcela Hakonarson, Hakon Porteous, David J. Below, Jennifer Richmond, Anne Chang, Xiao Polikowski, Hannah Lauren, Petty E. Chen, Hung-Hsin Wanying, Zhu Fawns-Ritchie, Chloe North, Kari McCormick, Joseph B. Glessner, Joseph R. Gignoux, Christopher R. Wicks, Stephen J. Crooks, Kristy Barnes, Kathleen C. Daya, Michelle Shortt, Jonathan Rafaels, Nichola Chavan, Sameer Timmers, Paul R. H. J. Wilson, James F. Tenesa, Albert Kerr, Shona M. D’Mellow, Kenton Shahin, Doaa El-Sherbiny, Yasser M. von Hohenstaufen, Kathrin Aprile Sobh, Ali Eltoukhy, Madonna M. Nkambul, Lindokuhle Elhadidy, Tamer A. Abd Elghafar, Mohamed S. El-Jawhari, Jehan J. Mohamed, Attia A. S. Elnagdy, Marwa H. Samir, Amr Abdel-Aziz, Mahmoud Khafaga, Walid T. El-Lawaty, Walaa M. Torky, Mohamed S. El-shanshory, Mohamed R. Yassen, Amr M. Hegazy, Mohamed A. F. Okasha, Kamal Eid, Mohammed A. Moahmed, Hanteera S. Medina-Gomez, Carolina Ikram, M. Arfan Uitterlinden, Andre G. Mägi, Reedik Milani, Lili Metspalu, Andre Laisk, Triin Läll, Kristi Lepamets, Maarja Esko, Tõnu Reimann, Ene Naaber, Paul Laane, Edward Pesukova, Jaana Peterson, Pärt Kisand, Kai Tabri, Jekaterina Allos, Raili Hensen, Kati Starkopf, Joel Ringmets, Inge Tamm, Anu Kallaste, Anne Alavere, Helene Metsalu, Kristjan Puusepp, Mairo Batini, Chiara Tobin, Martin D. Venn, Laura D. Lee, Paul H. Shrine, Nick Williams, Alexander T. Guyatt, Anna L. John, Catherine Packer, Richard J. Ali, Altaf Free, Robert C. Wang, Xueyang Wain, Louise V. Hollox, Edward J. Bee, Catherine E. Adams, Emma L. Palotie, Aarno Ripatti, Samuli Ruotsalainen, Sanni Kristiansson, Kati Koskelainen, Sami Perola, Marku Donner, Kati Kivinen, Katja Kaunisto, Mari Rivolta, Carlo Bochud, Pierre-Yve Bibert, Stéphanie Boillat, Noémie Nussle, Semira Gonseth Albrich, Werner Quinodoz, Mathieu Kamdar, Dhryata Suh, Noémie Neofytos, Dionysio Erard, Véronique Voide, Cathy Friolet, R. Vollenweider, P. Pagani, J. L. Oddo, M. zu Bentrup, F. Meyer Conen, A. Clerc, O. Marchetti, O. Guillet, A. Guyat-Jacques, C. Foucras, S. Rime, M. Chassot, J. Jaquet, M. Viollet, R. Merlet Lannepoudenx, Y. Portopena, L. Bochud, P. Y. Desgranges, F. Filippidis, P. Guéry, B. Haefliger, D. Kampouri, E. E. Manuel, O. Munting, A. Papadimitriou-Olivgeris, M. Regina, J. Rochat-Stettler, L. Suttels, V. Tadini, E. Tschopp, J. Van Singer, M. Viala, B. Boillat-Blanco, N. Brahier, T. Hügli, O. Meuwly, J. Y. Pantet, O. Gonseth Nussle, S. Bochud, M. D’Acremont, V. Estoppey Younes, S. Albrich, W. C. Suh, N. Cerny, A. O’Mahony, L. von Mering, C. Frischknecht, M. Kleger, G-R. Filipovic, M. Kahlert, C. R. Wozniak, H. Negro, T. Rochat Pugin, J. Bouras, K. Knapp, C. Egger, T. Perret, A. Montillier, P. di Bartolomeo, C. Barda, B. de Cid, Rafael Carreras, Anna Moreno, Victor Kogevinas, Manoli Galván-Femenía, Iván Blay, Natalia Farré, Xavier Sumoy, Lauro Cortés, Beatriz Mercader, Josep Maria Guindo-Martinez, Marta Torrents, David Garcia-Aymerich, Judith Castaño-Vinyals, Gemma Dobaño, Carlota Gori, Marco Renieri, Alessandra Mari, Francesca Mondelli, Mario Umberto Castelli, Francesco Vaghi, Massimo Rusconi, Stefano Montagnani, Francesca Bargagli, Elena Franchi, Federico Mazzei, Maria Antonietta Cantarini, Luca Tacconi, Danilo Feri, Marco Scala, Raffaele Spargi, Genni Nencioni, Cesira Bandini, Maria Caldarelli, Gian Piero Canaccini, Anna Ognibene, Agostino D’Arminio Monforte, Antonella Girardis, Massimo Antinori, Andrea Francisci, Daniela Schiaroli, Elisabetta Scotton, Pier Giorgio Panese, Sandro Scaggiante, Renzo Monica, Matteo Della Capasso, Mario Fiorentino, Giuseppe Castori, Marco Aucella, Filippo Biagio, Antonio Di Masucci, Luca Valente, Serafina Mandalà, Marco Zucchi, Patrizia Giannattasio, Ferdinando Coviello, Domenico A. Mussini, Cristina Tavecchia, Luisa Crotti, Lia Rizzi, Marco Rovere, Maria Teresa La Sarzi-Braga, Simona Bussotti, Maurizio Ravaglia, Sabrina Artuso, Rosangela Perrella, Antonio Romani, Davide Bergomi, Paola Catena, Emanuele Vincenti, Antonella Ferri, Claudio Grassi, Davide Pessina, Gloria Tumbarello, Mario Pietro, Massimo Di Sabrina, Ravaglia Luchi, Sauro Furini, Simone Dei, Simona Benetti, Elisa Picchiotti, Nicola Sanarico, Maurizio Ceri, Stefano Pinoli, Pietro Raimondi, Francesco Biscarini, Filippo Stella, Alessandra Zguro, Kristina Capitani, Katia Tanfoni, Marco Fallerini, Chiara Daga, Sergio Baldassarri, Margherita Fava, Francesca Frullanti, Elisa Valentino, Floriana Doddato, Gabriella Giliberti, Annarita Tita, Rossella Amitrano, Sara Bruttini, Mirella Croci, Susanna Meloni, Ilaria Mencarelli, Maria Antonietta Rizzo, Caterina Lo Pinto, Anna Maria Beligni, Giada Tommasi, Andrea Sarno, Laura Di Palmieri, Maria Carriero, Miriam Lucia Alaverdian, Diana Busani, Stefano Bruno, Raffaele Vecchia, Marco Belli, Mary Ann Mantovani, Stefania Ludovisi, Serena Quiros-Roldan, Eugenia Antoni, Melania Degli Zanella, Isabella Siano, Matteo Emiliozzi, Arianna Fabbiani, Massimiliano Rossetti, Barbara Bergantini, Laura D’Alessandro, Miriana Cameli, Paolo Bennett, David Anedda, Federico Marcantonio, Simona Scolletta, Sabino Guerrini, Susanna Conticini, Edoardo Frediani, Bruno Spertilli, Chiara Donati, Alice Guidelli, Luca Corridi, Marta Croci, Leonardo Piacentini, Paolo Desanctis, Elena Cappelli, Silvia Verzuri, Agnese Anemoli, Valentina Pancrazzi, Alessandro Lorubbio, Maria Miraglia, Federica Gaia Venturelli, Sophie Cossarizza, Andrea Vergori, Alessandra Gabrieli, Arianna Riva, Agostino Paciosi, Francesco Andretta, Francesca Gatti, Francesca Parisi, Saverio Giuseppe Baratti, Stefano Piscopo, Carmelo Russo, Roberta Andolfo, Immacolata Iolascon, Achille Carella, Massimo Merla, Giuseppe Squeo, Gabriella Maria Raggi, Pamela Marciano, Carmen Perna, Rita Bassetti, Matteo Sanguinetti, Maurizio Giorli, Alessia Salerni, Lorenzo Parravicini, Pierpaolo Menatti, Elisabetta Trotta, Tullio Coiro, Gabriella Lena, Fabio Martinelli, Enrico Mancarella, Sandro Gabbi, Chiara Maggiolo, Franco Ripamonti, Diego Bachetti, Tiziana Suardi, Claudia Parati, Gianfranco Bottà, Giordano Domenico, Paolo Di Rancan, Ilaria Bianchi, Francesco Colombo, Riccardo Barbieri, Chiara Acquilini, Donatella Andreucci, Elena Segala, Francesco Vladimiro Tiseo, Giusy Falcone, Marco Lista, Mirjam Poscente, Monica Vivo, Oreste De Petrocelli, Paola Guarnaccia, Alessandra Baroni, Silvia van Heel, David A. Hunt, Karen A. Trembath, Richard C. Huang, Qin Qin Martin, Hilary C. Mason, Dan Trivedi, Bhavi Wright, John Finer, Sarah Akhtar, Shaheen Anwar, Mohammad Arciero, Elena Ashraf, Samina Breen, Gerome Chung, Raymond Curtis, Charles J. Chowdhury, Maharun Colligan, Grainne Deloukas, Pano Durham, Ceri Griffiths, Chri Hurles, Matt Hussain, Shapna Islam, Kamrul Khan, Ahsan Khan, Amara Lavery, Cath Lee, Sang Hyuck Lerner, Robin MacArthur, Daniel MacLaughlin, Bev Martin, Hilary Miah, Shefa Newman, Bill Safa, Nishat Tahmasebi, Farah Griffiths, Christopher J. Smith, Albert V. Boughton, Andrew P. Li, Kevin W. LeFaive, Jonathon Annis, Aubrey Niavarani, Ahmadreza Aliannejad, Rasoul Sharififard, Bahareh Amirsavadkouhi, Ali Naderpour, Zeinab Tadi, Hengameh Ansari Aleagha, Afshar Etemadi Ahmadi, Saeideh Moghaddam, Seyed Behrooz Mohseni Adamsara, Alireza Saeedi, Morteza Abdollahi, Hamed Hosseini, Abdolmajid Chariyavilaskul, Pajaree Jantarabenjakul, Watsamon Hirankarn, Nattiya Chamnanphon, Monpat Suttichet, Thitima B. Shotelersuk, Vorasuk Pongpanich, Monnat Phokaew, Chureerat Chetruengchai, Wanna Putchareon, Opa Torvorapanit, Pattama Puthanakit, Thanyawee Suchartlikitwong, Pintip Nilaratanakul, Voraphoj Sodsai, Pimpayao Brumpton, Ben M. Hveem, Kristian Willer, Cristen Zhou, Wei Rogne, Tormod Solligard, Erik Åsvold, Bjørn Olav Franke, Lude Boezen, Marike Deelen, Patrick Claringbould, Annique Lopera, Esteban Warmerdam, Robert Vonk, Judith. M. van Blokland, Irene Lanting, Pauline Ori, Anil P. S. Feng, Yen-Chen Anne Mercader, Josep Weiss, Scott T. Karlson, Elizabeth W. Smoller, Jordan W. Murphy, Shawn N. Meigs, James B. Woolley, Ann E. Green, Robert C. Perez, Emma F. Zöllner, Sebastian Wang, Jiongming Beck, Andrew Sloofman, Laura G. Ascolillo, Steven Sebra, Robert P. Collins, Brett L. Levy, Te Buxbaum, Joseph D. Sealfon, Stuart C. Jordan, Daniel M. Thompson, Ryan C. Gettler, Kyle Chaudhary, Kumardeep Belbin, Gillian M. Preuss, Michael Hoggart, Clive Choi, Sam Underwood, Slayton J. Salib, Irene Britvan, Bari Keller, Katherine Tang, Lara Peruggia, Michael Hiester, Liam L. Niblo, Kristi Aksentijevich, Alexandra Labkowsky, Alexander Karp, Avromie Zlatopolsky, Menachem Zyndorf, Marissa Charney, Alexander W. Beckmann, Noam D. Schadt, Eric E. Abul-Husn, Noura S. Cho, Judy H. Itan, Yuval Kenny, Eimear E. Loos, Ruth J. F. Nadkarni, Girish N. Do, Ron O’Reilly, Paul Huckins, Laura M. Ferreira, Manuel A. R. Abecasis, Goncalo R. Leader, Joseph B. Cantor, Michael N. Justice, Anne E. Carey, Dave J. Chittoor, Geetha Josyula, Navya Shilpa Kosmicki, Jack A. Horowitz, Julie E. Baras, Ari Gass, Matthew C. Yadav, Ashish Mirshahi, Tooraj Hottenga, Jouke Jan Bartels, Meike de geus, Eco E. J. C. Nivard, Michel M. G. Verma, Anurag Ritchie, Marylyn D. Rader, Daniel Li, Binglan Verma, Shefali S. Lucas, Anastasia Bradford, Yuki Abedalthagafi, Malak Alaamery, Manal Alshareef, Abdulraheem Sawaji, Mona Massadeh, Salam AlMalik, Abdulaziz Alqahtani, Saleh Baraka, Dona Harthi, Fawz Al Alsolm, Ebtehal Safieh, Leen Abu Alowayn, Albandary M. Alqubaishi, Fatimah Mutairi, Amal Al Mangul, Serghei Almutairi, Mansour Aljawini, Nora Albesher, Nour Arabi, Yaseen M. Mahmoud, Ebrahim S. Khattab, Amin K. Halawani, Roaa T. Alahmadey, Ziab Z. Albakri, Jehad K. Felemban, Walaa A. Suliman, Bandar A. Hasanato, Rana Al-Awdah, Laila Alghamdi, Jahad AlZahrani, Deema AlJohani, Sameera Al-Afghani, Hani AlDhawi, Nouf AlBardis, Hadeel Alkwai, Sarah Alswailm, Moneera Almalki, Faisal Albeladi, Maha Almohammed, Iman Barhoush, Eman Albader, Anoud Alotaibi, Sara Alghamdi, Bader Jung, Junghyun fawzy, Mohammad S. Alrashed, May Zeberg, Hugo Nkambul, Lindo Frithiof, Robert Hultström, Michael Lipcsey, Miklo Tardif, Nicola Rooyackers, Olav Grip, Jonathan Maricic, Tomislav Helgeland, Øyvind Magnus, Per Trogstad, Lill-Iren S. Lee, Yunsung Harris, Jennifer R. Mangino, Massimo Spector, Tim D. Emma, Duncan Moutsianas, Louka Caulfield, Mark J. Scott, Richard H. Kousathanas, Athanasio Pasko, Dorota Walker, Susan Stuckey, Alex Odhams, Christopher A. Rhodes, Daniel Fowler, Tom Rendon, Augusto Chan, Georgia Arumugam, Prabhu Karczewski, Konrad J. Martin, Alicia R. Wilson, Daniel J. Spencer, Chris C. A. Crook, Derrick W. Wyllie, David H. O’Connell, Anne Marie Atkinson, Elizabeth G. 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Lozano, Francisco Domingo, Carlo Robles, Veronica Ruiz-Jaén, Francisca Márquez, Leonardo Gomez, Juan Coto, Eliecer Albaiceta, Guillermo M. García-Clemente, Marta Dalmau, David Arranz, Maria J. Dietl, Beatriz Serra-Llovich, Alex Soler, Pere Colobrán, Roger Martín-Nalda, Andrea Martínez, Alba Parra Bernardo, David Rojo, Silvia Fiz-López, Aida Arribas, Elisa de la Cal-Sabater, Paloma Segura, Tomá González-Villa, Esther Serrano-Heras, Gemma Martí-Fàbregas, Joan Jiménez-Xarrié, Elena de Felipe Mimbrera, Alicia Masjuan, Jaime García-Madrona, Sebastian Domínguez-Mayoral, Anna Villalonga, Joan Montaner Menéndez-Valladares, Paloma Chasman, Daniel I. Sesso, Howard D. Manson, JoAnn E. Buring, Julie E. Ridker, Paul M. Franco, Giulianini Davis, Lea Lee, Sulggi Priest, Jame Sankaran, Vijay G. van Heel, David Biesecker, Le Kerchberger, V. Eric Baillie, J. Kenneth APH - Personalized Medicine APH - Health Behaviors & Chronic Diseases Biological Psychology APH - Mental Health AMS - Sports AMS - Ageing & Vitality APH - Methodology Mccurdy, Shannon Mccormick, Joseph B. Macarthur, Daniel Maclaughlin, Bev Lefaive, Jonathon Almalik, Abdulaziz Alzahrani, Deema Aljohani, Sameera Aldhawi, Nouf Albardis, Hadeel Fawzy, Mohammad S. Dediego, Marta L. Stem Cell Aging Leukemia and Lymphoma (SALL) Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI) Life Course Epidemiology (LCE) Groningen Research Institute for Asthma and COPD (GRIAC) University of Zurich COVID-19 Host Genetics Initiative Barcelona Supercomputing Center COVID-19 Genetics Initiative including authors Institute for Molecular Medicine Finland Data Science Genetic Epidemiology Lab
Source :
Nature, 608(7921), E1-E10. Nature Publishing Group, Nature, 608. Nature Publishing Group, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), Nature, r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe, instname, COVID-19 Host Genetics Initiative, Hottenga, J J, Bartels, M, de Geus, E J C & Nivard, M 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7, 2022, ' A first update on mapping the human genetic architecture of COVID-19 ', Nature, vol. 608, no. 7921, pp. E1-E10 . https://doi.org/10.1038/s41586-022-04826-7
Publication Year :
2022
Publisher :
Nature Publishing Group, 2022.
Abstract
Matters arising from: Mapping the human genetic architecture of COVID-19 Original Article published on 08 July 2021 https://www.nature.com/articles/s41586-021-03767-x The COVID-19 pandemic continues to pose a major public health threat, especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity, we formed the COVID-19 Host Genetics Initiative1. Here we present a genome-wide association study meta-analysis of up to 125,584 cases and over 2.5 million control individuals across 60 studies from 25 countries, adding 11 genome-wide significant loci compared with those previously identified2. Genes at new loci, including SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity. Here we present meta-analyses bringing together 60 studies from 25 countries (Fig. 1 and Supplementary Table 1) for three COVID-19-related phenotypes: (1) individuals critically ill with COVID-19 on the basis of requiring respiratory support in hospital or who died as a consequence of the disease (9,376 cases, of which 3,197 are new in this data release, and 1,776,645 control individuals); (2) individuals with moderate or severe COVID-19 defined as those hospitalized due to symptoms associated with the infection (25,027 cases, 11,386 new and 2,836,272 control individuals); and (3) all cases with reported SARS-CoV-2 infection regardless of symptoms (125,584 cases, 76,022 new and 2,575,347 control individuals). Most studies have reported results before the roll out of the COVID-19 vaccination campaign. An overview of the study design is provided in Supplementary Fig. 1. We found a total of 23 genome-wide significant loci (P
Details
Language :
English
ISSN :
00280836
Volume :
608
Issue :
7921
Database :
OpenAIRE
Journal :
Nature
Accession number :
edsair.doi.dedup.....827cbe7f6ea8d3fe660425d3d9cc06f9