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Novel antiphospholipid antibodies in autoimmune bullous diseases
- Source :
- Human Antibodies. 23:27-30
- Publication Year :
- 2015
- Publisher :
- IOS Press, 2015.
-
Abstract
- Background Pemphigus and bullous pemphigoid are two autoimmune diseases that have similar pathogenesis. Both have a genetic predisposition, which promotes the production of auto antibodies targeted against different components of the epidermal desmosome and hemidesmosome. Antiphospholipid antibodies (aPL) are heterogeneous group of antibodies found in patients with autoimmune diseases and inflammatory conditions and are associated with thrombotic events. Objective We sought to determine the expression profile of eight non classical aPLs in ABD patients. Methods A cohort of 266 serum samples of patients with pemphigus, bullous pemphigoid and controls was screened for the presence of eight aPL antibodies, using the Bio-Rad BioPlex™ 2200 system. Results Phosphatidylserine-beta-2-glycoprotein-I (aPS-β2GPI) and anti prothrombin complex (aPT-PT) serum profiles were significantly more prevalent among ABD patients; 20.7% patients with ABD compared to 5.9% of control patients were positive for aPS-β2GPI IgM. In addition, aPT-PT IgM was more prevalent among ABD patients (31% vs. 14.8%). Conclusion aPL auto antibodies are more prevalent in ABD. Any clinical association should be further determined.
- Subjects :
- Male
Immunology
Autoimmunity
medicine.disease_cause
Pathogenesis
immune system diseases
Desmosome
Pemphigoid, Bullous
Genetic predisposition
Humans
Immunology and Allergy
Medicine
Genetic Predisposition to Disease
Aged
Aged, 80 and over
integumentary system
biology
business.industry
Autoantibody
General Medicine
Middle Aged
medicine.disease
Pemphigus
medicine.anatomical_structure
Immunoglobulin M
beta 2-Glycoprotein I
Case-Control Studies
Antibodies, Antiphospholipid
biology.protein
Female
Prothrombin
Bullous pemphigoid
Antibody
business
Subjects
Details
- ISSN :
- 1875869X and 10932607
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Human Antibodies
- Accession number :
- edsair.doi.dedup.....828143a213ca1db9271841c451ecd739