Back to Search Start Over

The Detection of Vascular Endothelial Growth Factor in Serum of Patients with Hemorrhagic Fever with Renal Syndrome

Authors :
Ming Xie
Yuqiang Ji
Yanying Dong
Man Li
Huixun Ren
Yan Zhou
Source :
Inflammation. 36:962-967
Publication Year :
2013
Publisher :
Springer Science and Business Media LLC, 2013.

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease characterized by endothelial cell dysfunction, which results in plasma exosmosis, hyperpermeability, and sometimes hemorrhages. As one of the vascular permeability cytokines, vascular endothelial growth factor (VEGF) might mediate the hyperpermeability caused by HFRS. In the present study, the levels of serum VEGF were measured by competitive inhibition ELISA. We found variable but persistently elevated levels of VEGF throughout the various stages and types of HFRS disease, which suggested that the levels of VEGF were closely correlated to the progression of HFRS. Moreover, elevated levels of VEGF have correlation with the severity and degree of kidney damage. Therefore, to study the relationship between levels of VEGF and disease severity of patients with HFRS is helpful to clarify the pathogenesis of HFRS.

Details

ISSN :
15732576 and 03603997
Volume :
36
Database :
OpenAIRE
Journal :
Inflammation
Accession number :
edsair.doi.dedup.....82a7e7c31b806078a09f26bd0111a7bf
Full Text :
https://doi.org/10.1007/s10753-013-9627-x