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The Detection of Vascular Endothelial Growth Factor in Serum of Patients with Hemorrhagic Fever with Renal Syndrome
- Source :
- Inflammation. 36:962-967
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- Hemorrhagic fever with renal syndrome (HFRS) is an acute infectious disease characterized by endothelial cell dysfunction, which results in plasma exosmosis, hyperpermeability, and sometimes hemorrhages. As one of the vascular permeability cytokines, vascular endothelial growth factor (VEGF) might mediate the hyperpermeability caused by HFRS. In the present study, the levels of serum VEGF were measured by competitive inhibition ELISA. We found variable but persistently elevated levels of VEGF throughout the various stages and types of HFRS disease, which suggested that the levels of VEGF were closely correlated to the progression of HFRS. Moreover, elevated levels of VEGF have correlation with the severity and degree of kidney damage. Therefore, to study the relationship between levels of VEGF and disease severity of patients with HFRS is helpful to clarify the pathogenesis of HFRS.
- Subjects :
- Vascular Endothelial Growth Factor A
Pathology
medicine.medical_specialty
Immunology
Vascular permeability
Severity of Illness Index
Blood Urea Nitrogen
Pathogenesis
chemistry.chemical_compound
medicine
Humans
Immunology and Allergy
Kidney
Creatinine
Proteinuria
business.industry
Acute kidney injury
virus diseases
Acute Kidney Injury
medicine.disease
Vascular endothelial growth factor
Vascular endothelial growth factor A
medicine.anatomical_structure
chemistry
Hemorrhagic Fever with Renal Syndrome
medicine.symptom
business
Subjects
Details
- ISSN :
- 15732576 and 03603997
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Inflammation
- Accession number :
- edsair.doi.dedup.....82a7e7c31b806078a09f26bd0111a7bf
- Full Text :
- https://doi.org/10.1007/s10753-013-9627-x