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Association between HER-2/neu and the progesterone receptor in oestrogen-dependent breast cancer is age-related
- Source :
- Breast cancer research and treatment, 91(1), 81-87. Springer New York
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- In oestrogen receptor-positive (ER+) breast cancer, HER-2/neu and the progesterone receptor (PR) are inversely associated. This explains a lower response to anti-oestrogens if ER+ breast cancers are HER-2/neu positive. One randomized study however, showed that premenopausal women with an ER+ breast cancer respond to anti-oestrogens independent of HER-2/neu. We therefore hypothesized an age-related association between HER-2/neu and PR in ER+ breast cancers. Receptors for ER, PR and HER-2/neu were analysed by immunohistochemistry (IHC). A uni- and multivariate analyses was carried out to assess this relationship in 1104 women with an ER+ breast cancer. We observed an inverse association between HER-2/neu and PR only after age 45. There were 173 women of age 45 years. In multivariate analysis, only tumour grade (p=0.005) but not PR status was associated with HER-2/neu in women age 45 years group, both PR status (p=0.001) and tumour grade (p=0.001) were independently associated with HER-2/neu. In ER+ breast cancers from women age>45, PR was positive in 76.9% if HER-2/neu negative but in 53.4% if HER-2/neu positive (p 45 years but not in women age
- Subjects :
- Adult
Aging
Cancer Research
medicine.medical_specialty
Receptor, ErbB-2
Breast Neoplasms
Biology
Tumor grade
Breast cancer
Predictive Value of Tests
Her 2 neu
Internal medicine
Age related
Progesterone receptor
Biomarkers, Tumor
medicine
Humans
Receptor
Aged
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Postmenopause
Endocrinology
Premenopause
Receptors, Estrogen
Oncology
Hormone receptor
Multivariate Analysis
Female
Receptors, Progesterone
Subjects
Details
- ISSN :
- 15737217 and 01676806
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research and Treatment
- Accession number :
- edsair.doi.dedup.....82ba489c3268969847317bd9602328e8