Construction of versatile multilayered composite nanoparticles from a customized nanogel template

We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize “smart” biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.
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Highlights • A highly adaptable design platform for multi-responsive, multilayered composite nanoparticles. • A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method. • Sequential assembly of multilayered NPs with a nanogel template, porous silica shell, pH-responsive PAA layer, and hydroxyapatite coating. • The ability to finely tune the structure and function of each layer.