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Associations of Mycobacterium tuberculosis genotypes with different ethnic and migratory populations in Taiwan
- Source :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 8(3)
- Publication Year :
- 2007
-
Abstract
- The distribution of human Mycobacterium tuberculosis (MTB) genotypes is reportedly associated with geography, ethnicity and population migrations. Three groups of 208 patients with tuberculosis in Taiwan were sampled to test this observation: (1) 41 aborigines of Austronesian ethnicity, who have been inhabiting in Taiwan for more than 500 years; (2) 58 veterans of Han Chinese origin, who moved as the first generation from Mainland China to Taiwan 55-60 years ago; and (3) 109 patients representing the general Taiwanese population of Han Chinese whose ancestors migrated to Taiwan around 200-400 years ago. A total of 208 MTB isolates, one per patient, were analyzed by spoligotyping and mycobacterial interspersed repetitive unit (MIRU) typing. Beijing ancient strains and Haarlem strains predominated among aborigines, while Beijing modern strains were common among veterans and the general population. All Beijing strains were further analyzed by typing the NTF loci and RD deletion. Results suggest a chronological trend among Beijing isolates from the three groups: isolates from the aborigines had signatures compatible with ancient lineages, and those from veterans and the general population were more contemporary. Our data indicate that the distribution of MTB genotypes/strains in Taiwan is associated with different populations whose migratory activities occurred between 55 and 500 years ago. These results suggest that transmission of MTB may have been relatively restricted to close contacts.
- Subjects :
- Microbiology (medical)
Mainland China
Tuberculosis
Genotype
Population
Ethnic group
Taiwan
Emigrants and Immigrants
Microbiology
Mycobacterium tuberculosis
Beijing
Genetics
medicine
Humans
Typing
education
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Phylogeny
education.field_of_study
biology
biology.organism_classification
medicine.disease
Infectious Diseases
Demography
Subjects
Details
- ISSN :
- 15671348
- Volume :
- 8
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Accession number :
- edsair.doi.dedup.....82d10334228cf86a4de2d1f3a920a7a4