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HOXA11‐AS promotes the growth and invasion of renal cancer by sponging miR‐146b‐5p to upregulate MMP16 expression
- Source :
- Journal of Cellular Physiology. 233:9611-9619
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Recently, increasing studies showed that long noncoding RNAs (lncRNAs) play critical roles in tumor progression. However, the function and underlying mechanism of HOMEOBOX A11 antisense RNA (HOXA11-AS) on renal cancer remain unclear. In the current study, our data showed that the expression of HOXA11-AS was significantly upregulated in clear cell renal cell carcinoma (ccRCC) tissues and cell lines. High HOXA11-AS expression was associated with the advanced clinical stage, tumor stage, and lymph node metastasis. Function assays showed that HOXA11-AS inhibition significantly suppressed renal cancer cells growth, invasion, and ETM phenotype. In addition, underlying mechanism revealed that HOXA11-AS could act as a competing endogenous RNA (ceRNA) that repressed miR-146b-5p expression, which regulated its downstream target MMP16 in renal cancer. Taken together, our findings suggested that HOXA11-AS could promote renal cancer cells growth and invasion by modulating miR-146b-5p-MMP16 axis. Thus, our findings suggested that HOXA11-AS could serve as potential therapeutic target for the treatment of renal cancer.
- Subjects :
- Male
0301 basic medicine
Physiology
Clinical Biochemistry
Mice, Nude
Biology
03 medical and health sciences
0302 clinical medicine
Downregulation and upregulation
Cell Line, Tumor
medicine
Animals
Humans
Neoplasm Invasiveness
Carcinoma, Renal Cell
Aged
Cell Proliferation
Base Sequence
Competing endogenous RNA
Cancer
Matrix Metalloproteinase 16
Cell Biology
Middle Aged
medicine.disease
Kidney Neoplasms
Up-Regulation
Antisense RNA
Gene Expression Regulation, Neoplastic
MicroRNAs
Clear cell renal cell carcinoma
030104 developmental biology
Tumor progression
Gene Knockdown Techniques
030220 oncology & carcinogenesis
Cancer cell
Disease Progression
Cancer research
Female
RNA, Long Noncoding
MMP16
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....82df1f78cfaab91ae732e148f2126e6a