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'Omic' Approaches to Study Uropathogenic Escherichia coli Virulence
- Source :
- Trends in microbiology. 25(9)
- Publication Year :
- 2017
-
Abstract
- Uropathogenic Escherichia coli (UPEC) is a pathogen of major significance to global human health and is strongly associated with rapidly increasing antibiotic resistance. UPEC is the primary cause of urinary tract infection (UTI), a disease that involves a complicated pathogenic pathway of extracellular and intracellular lifestyles during interaction with the host. The application of multiple ‘omic’ technologies, including genomics, transcriptomics, proteomics, and metabolomics, has provided enormous knowledge to our understanding of UPEC biology. Here we outline this progress and present a view for future developments using these exciting forefront technologies to fully comprehend UPEC pathogenesis in the context of infection.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Proteomics
Virulence
Genomics
Context (language use)
Disease
Computational biology
Biology
urologic and male genital diseases
medicine.disease_cause
Microbiology
Mass Spectrometry
03 medical and health sciences
Antibiotic resistance
Virology
medicine
Escherichia coli
Humans
Metabolomics
Uropathogenic Escherichia coli
Pathogen
Escherichia coli Infections
Escherichia coli Proteins
High-Throughput Nucleotide Sequencing
bacterial infections and mycoses
female genital diseases and pregnancy complications
030104 developmental biology
Infectious Diseases
Biofilms
Urinary Tract Infections
Transcriptome
Subjects
Details
- ISSN :
- 18784380
- Volume :
- 25
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Trends in microbiology
- Accession number :
- edsair.doi.dedup.....82eb50bcee7f404022a96a2a2d4f41e6