Back to Search
Start Over
Peak C-Reactive Protein Concentration Correlates With Left Ventricular Thrombus Formation Diagnosed by Contrast Echocardiographic Left Ventricular Opacification in Patients With a First Anterior Acute Myocardial Infarction
- Source :
- Circulation Journal. 70:1290-1296
- Publication Year :
- 2006
- Publisher :
- Japanese Circulation Society, 2006.
-
Abstract
- Wall motion abnormality in the apical legion of the left ventricle (LV) with stagnant flow alone is not sufficient to identify patients at high risk for LV thrombus formation among those with first anterior acute myocardial infarction (AMI). The aim of this study was to identify the determinants of LV thrombus formation using contrast echocardiography.In 75 patients with first anterior AMI, standard and contrast echocardiography was performed to detect LV thrombus. Although LV thrombus was found in 10 patients (13%) using standard echocardiography, it was found in 15 patients (20%) using contrast echocardiography. Apical stagnant flow was observed in 14 patients (93%) with LV thrombus. In addition, patients with LV thrombus had a higher peak C-reactive protein (CRP) concentration (18.2+/-4.3 vs 7.9+/-5.5 mg/dl, p0.0001). In multivariate analysis, only peak CRP concentration was identified as an independent predictor of LV thrombus (p=0.02, odds ratio: 1.400, confidence interval: 1.040-1.884). The receiver-operating characteristics (ROC) analysis revealed the best cutoff value of a peak CRP concentration10.7 mg/dl to identify patients with LV thrombus (sensivity 0.93, specificity 0.75, area under ROC curve 0.91).The peak CRP concentration is a useful marker of patients with first anterior AMI who are at high risk for LV thrombus.
- Subjects :
- Male
medicine.medical_specialty
Myocardial Infarction
Sensitivity and Specificity
Ventricular Dysfunction, Left
Predictive Value of Tests
Internal medicine
medicine
Humans
In patient
Prospective Studies
cardiovascular diseases
Myocardial infarction
Wall motion
Thrombus
Aged
biology
business.industry
Coronary Thrombosis
C-reactive protein
General Medicine
Middle Aged
Left ventricular thrombus
medicine.disease
C-Reactive Protein
medicine.anatomical_structure
ROC Curve
Echocardiography
Ventricle
Contrast echocardiography
biology.protein
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....82ee57fd2d7229a5a3d639d540c7ea8c