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Hypofractionated radiotherapy for early glottic cancer: a retrospective interim analysis of a single institution
- Source :
- Radiation Oncology Journal
- Publication Year :
- 2019
- Publisher :
- Korean Society for Therapeutic Radiology and Oncology, 2019.
-
Abstract
- Purpose To evaluate the results of hypofractionated radiotherapy (HFX) for early glottic cancer. Materials and Methods Eighty-five patients with cT1-2N0M0 squamous cell carcinoma of the glottis who had undergone HFX, performed using intensity-modulated radiotherapy (IMRT, n = 66) and three-dimensional conformal radiotherapy (3D CRT, n = 19) were analyzed. For all patients, radiotherapy was administered at 60.75 Gy in 27 fractions. Forty-three patients received a simultaneous integrated boost (SIB) of 2.3–2.5 Gy per tumor fraction. Results The median follow-up duration was 29.9 months (range, 5.5 to 76.5 months). All patients achieved complete remission at a median of 50 days after the end of radiotherapy (range, 14 to 206 days). The 5-year rates for locoregional recurrence-free survival was 88.1%, and the 5-year overall survival rate was 86.2%. T2 stage was a prognostic factor for locoregional recurrence-free survival after radiotherapy (p = 0.002). SIB for the tumor did not affect disease control and survival (p = 0.191 and p = 0.387, respectively). No patients experienced acute or chronic toxicities of ≥grade 3. IMRT significantly decreased the dose administered to the carotid artery as opposed to 3D CRT (V35, p < 0.001; V50, p < 0.001). conclusions Patients treated with HFX achieved acceptable locoregional disease control rates and overall survival rates compared with previous HFX studies. A fraction size of 2.25 Gy provided good disease control regardless of SIB administration.
- Subjects :
- Simultaneous integrated boost
Hypofractionated Radiotherapy
Glottis
medicine.medical_specialty
Intensity-modulated radiotherapy
medicine.medical_treatment
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Medicine
Radiology, Nuclear Medicine and imaging
Clinical Investigation
Single institution
Stage (cooking)
Radiotherapy
business.industry
Radiation dose hypofractionation
Interim analysis
Radiation therapy
medicine.anatomical_structure
Oncology
Glottic cancer
030220 oncology & carcinogenesis
Original Article
Radiology
business
Subjects
Details
- ISSN :
- 22343156 and 22341900
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Radiation Oncology Journal
- Accession number :
- edsair.doi.dedup.....82fad4d4f2610217bda9a88ed16eb62a