Back to Search
Start Over
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
- Source :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1171-1184. ⟨10.1038/ng.3667⟩, BASE-Bielefeld Academic Search Engine, Nature genetics, vol 48, iss 10, Nature Genetics, 48(10), 1171-1184. Nature Publishing Group, Nature Genetics, Vol. 48, No 10 (2016) pp. 1171-1184, Nature Genetics, 2016, 48 (10), pp.1171-1184. ⟨10.1038/ng.3667⟩, Ehret, G B, Ferreira, T, Chasman, D I, Jackson, A U, Schmidt, E M, Johnson, T, Thorleifsson, G, Luan, J, Donnelly, L A, Kanoni, S, Jansen, R, Boomsma, D I, Hottenga, J J, Penninx, B W J H, van Duijn, C M, Wichmann, H E, Palmer, C N A, Stefansson, K, Ridker, P M, Loos, R J F, Chakravarti, A, Deloukas, P, Morris, A P, Newton-Cheh, C & Munroe, P B 2016, ' The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals ', Nature Genetics, vol. 48, no. 10, pp. 1171-1184 . https://doi.org/10.1038/ng.3667, 2016, ' The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals ', Nature Genetics, vol. 48, no. 10, pp. 1171-1184 . https://doi.org/10.1038/ng.3667, Nature genetics, 48(10), 1171-1184. Nature Publishing Group, NATURE GENETICS, Ehret, G B, Ferreira, T, Chasman, D I, Jackson, A U, Schmidt, E M, Johnson, T, Thorleifsson, G, Luan, J, Donnelly, L A, Kanoni, S, Petersen, A-K, Pihurl, V, Strawbridge, R J, Shungin, D, Hughes, M F, Meirelles, O, Kaakinen, M, Bouatia-Naji, N, Kristiansson, K, Shah, S, Kleber, M E, Guo, X, Lyytikainen, L-P, Fava, C, Eriksson, N, Nolte, I M, Magnusson, P K, Salfati, E L, Rallidis, L S, Theusch, E, Smith, A J P, Folkersen, L, Witkowska, K, Pers, T H, Joehanes, R, Kim, S K, Lataniotis, L, Jansen, R, Johnson, A D, Warren, H, Kim, Y J, Zhao, W, Wu, Y, Tayo, B O, Bochud, M, Absher, D, Adair, L S, Amin, N, Arkingl, D E, Axelsson, T, Baldassarre, D, Balkau, B, Bandinelli, S, Barnes, M R, Barroso, I, Bevan, S, Bis, J C, Bjornsdottir, G, Boehnke, M, Boerwinkle, E, Bonnycastle, L L, Boomsma, D I, Bornstein, S R, Brown, M J, Burnier, M, Cabrera, C P, Chambers, J C, Chang, I-S, Cheng, C-Y, Chines, P S, Chung, R-H, Collins, F S, Connell, J M, Doring, A, Dallongeville, J, Danesh, J, de Faire, U, Delgado, G, Dominiczak, A F, Doney, A S F, Drenos, F, Edkins, S, Eicher, J D, Elosua, R, Enroth, S, Erdmann, J, Eriksson, P, Esko, T, Evangelou, E, Evans, A, Fai, T, Farra, M, Felixl, J F, Ferrieres, J, Ferrucci, L, Fornage, M, Forrester, T, Franceschinil, N, Franco, O H, Franco-Cereceda, A, Fraser, R M, Ganesh, S K, Gao, H, Gertow, K, Gianfagna, F, Gigante, B, Giulianini, F, Goe, A, Goodall, A H, Goodarzi, M, Gorski, M, Grassler, J, Groves, C J, Gudnason, V, Gyllensten, U, Hallmans, G, Hartikainen, A-L, Hassinen, M, Havulinna, A S, Hayward, C, Hercberg, S, Herzig, K-H, Hicks, A A, Hingorani, A D, Hirschhorn, J N, Hofmanl, A, Holmen, J, Holmen, O L, Hottenga, J-J, Howard, P, Hsiung, C A, Hunt, S C, Ikram, M A, Illig, T, Iribarren, C, Jensen, R A, Kahonen, M, Kang, H M, Kathiresan, S, Keating, B J, Khaw, K-T, Kim, Y K, Kim, E, Kivimaki, M, Klopp, N, Kolovou, G, Komulainen, P, Kooner, J S, Kosova, G, Krauss, R M, Kuh, D, Kutalik, Z, Kuusisto, J, Kvaloy, K, Lakka, T A, Lee, N R, Lee, I-T, Lee, W-J, Levy, D, Li, X, Liang, K-W, Lin, H, Lin, L, Lindstrom, J, Lobbens, S, Mannisto, S, Muller, G, Muller-Nurasyid, M, Mach, F, Markus, H S, Marouli, E, McCarthy, M I, McKenzie, C A, Meneton, P, Menni, C, Metspalu, A, Mijatovic, V, Moilanen, L, Montasser, M E, Morris, A D, Morrison, A C, Mulas, A, Nagaraja, R, Narisu, N, Nikus, K, O'Donnell, C J, O'Reilly, P F, Ong, K K, Paccaud, F, Palmer, C D, Parsa, A, Pedersen, N L, Penninx, B W, Perola, M, Peters, A, Poulter, N, Pramstaller, P P, Psaty, B M, Quertermous, T, Rao, D C, Rasheed, A, Rayner, N W, Renstrom, F, Rettig, R, Rice, K M, Roberts, R, Rose, L M, Rossouw, J, Samani, N J, Sanna, S, Saramies, J, Schunkert, H, Sebert, S, Sheu, W H-H, Shin, Y-A, Sim, X, Smit, J H, Smith, A V, Sosa, M X, Spector, T D, Stancakova, A, Stanton, A V, Stirrups, K E, Stringham, H M, Sundstrom, J, Swift, A J, Syvanen, A-C, Tai, E-S, Tanaka, T, Tarasov, K V, Teumer, A, Thorsteinsdottir, U, Tobin, M D, Tremoli, E, Uitterlinden, A G, Uusitupa, M, Vaez, A, Vaidya, D, van Duijn, C M, van Iperen, E P A, Vasan, R S, Verwoert, G C, Virtamo, J, Vitart, V, Voight, B F, Vollenweider, P, Wagner, A, Wain, L V, Wareham, N J, Watldns, H, Weder, A B, Westra, H J, Wilks, R, Wilsgaard, T, Wilson, J F, Wong, T Y, Yang, T-P, Yao, J, Yengo, L, Zhang, W, Zhao, J H, Zhu, X, Bovet, P, Cooper, R S, Mohlke, K L, Saleheen, D, Lee, J-Y, Elliott, P, Gierman, H J, Willer, C J, Franke, L, Hovingh, G K, Taylor, K D, Dedoussis, G, Sever, P, Wong, A, Lind, L, Assimes, T L, Njolstad, I, Schwarz, P E H, Langenberg, C, Snieder, H, Caulfield, M J, Melander, E, Laakso, M, Saltevo, J, Rauramaa, R, Tuomilehto, J, Ingelsson, E, Lehtimaki, T, Hveem, K, Palmas, W, Marz, W, Kumar, M, Salomaa, V, Chen, Y-D I, Rotter, J I, Froguel, P, Jarvelin, M-R, Lakatta, E G, Kuulasmaa, K, Franks, P W, Hamsten, A, Wichmann, H-E, Palmer, C N A, Stefansson, K, Ridker, P M, Loos, R J F, Chalcravarti, A, Deloukas, P, Morris, A P, Newton-Cheh, C & Munroe, P B 2016, ' The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals ', Nature Genetics, vol. 48, no. 10, pp. 1171-1184 . https://doi.org/10.1038/ng.3667, Nature genetics, vol. 48, no. 10, pp. 1171-1184
- Publication Year :
- 2016
- Publisher :
- HAL CCSD, 2016.
-
Abstract
- To dissect the genetic architecture of blood pressure (BP) and assess how its elevation promotes downstream cardiovascular diseases, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry. Genotypes from an additional 140,886 individuals of European ancestry were used as validation for loci reaching genome-wide significance but without prior support in the literature. We identified 66 BP loci, of which 17 were novel and 15 harbored multiple distinct association signals, and which together explain up to 3.5% of BP variation. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in BP control through modulating blood vessel tone and fluid filtration across multiple tissues, not solely the kidney. Importantly, the 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent (South-Asian, East-Asian and African), confirming that these are ancestral physiological effects that arose prior to human migration out of Africa. The 66-SNP BP risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our data expand current knowledge of BP pathways, and also, highlight that BP regulation and its effects may occur in multiple organs and tissues beyond the classic renal system.
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
CHROMATIN
[SDV]Life Sciences [q-bio]
LOCI
Genome-wide association study
Blood Pressure
SUSCEPTIBILITY
Bioinformatics
Cardiovascular
Genome-wide association studies
Medical and Health Sciences
single nucleotide polymorphism
CHARGE-EchoGen consortium
GWAS
2.1 Biological and endogenous factors
Aetiology
Cells, Cultured
African Continental Ancestry Group
Genetics & Heredity
Genetics
ddc:616
Kidney
Framingham Risk Score
Cultured
COMMON VARIANTS
11 Medical And Health Sciences
Single Nucleotide
Biological Sciences
African Continental Ancestry Group/genetics
Asian Continental Ancestry Group/genetics
Blood Pressure/genetics
Genome-Wide Association Study
Humans
Hypertension/genetics
Hypertension/pathology
Microarray Analysis
Polymorphism, Single Nucleotide
[SDV] Life Sciences [q-bio]
medicine.anatomical_structure
Hypertension/genetics/pathology
Hypertension
Medical genetics
Wellcome Trust Case Control Consortium
Life Sciences & Biomedicine
TRAITS
Biotechnology
Asian Continental Ancestry Group
medicine.medical_specialty
CHARGE-EchoGen Consortium
Cells
Black People
BIOLOGY
Single-nucleotide polymorphism
Biology
Blood pressure, hypertension, genetics, single nucleotide polymorphism, GWAS
03 medical and health sciences
SDG 3 - Good Health and Well-being
Asian People
medicine
Polymorphism
GENOME-WIDE ASSOCIATION
CELL-TYPES
METAANALYSIS
Genetic association
Science & Technology
CHARGE-HF consortium
06 Biological Sciences
Genetic architecture
030104 developmental biology
Blood pressure
CHARGE-HF Consortium
ARTERIAL-HYPERTENSION
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 10614036 and 15461718
- Database :
- OpenAIRE
- Journal :
- Nature Genetics, Nature Genetics, Nature Publishing Group, 2016, 48 (10), pp.1171-1184. ⟨10.1038/ng.3667⟩, BASE-Bielefeld Academic Search Engine, Nature genetics, vol 48, iss 10, Nature Genetics, 48(10), 1171-1184. Nature Publishing Group, Nature Genetics, Vol. 48, No 10 (2016) pp. 1171-1184, Nature Genetics, 2016, 48 (10), pp.1171-1184. ⟨10.1038/ng.3667⟩, Ehret, G B, Ferreira, T, Chasman, D I, Jackson, A U, Schmidt, E M, Johnson, T, Thorleifsson, G, Luan, J, Donnelly, L A, Kanoni, S, Jansen, R, Boomsma, D I, Hottenga, J J, Penninx, B W J H, van Duijn, C M, Wichmann, H E, Palmer, C N A, Stefansson, K, Ridker, P M, Loos, R J F, Chakravarti, A, Deloukas, P, Morris, A P, Newton-Cheh, C & Munroe, P B 2016, ' The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals ', Nature Genetics, vol. 48, no. 10, pp. 1171-1184 . https://doi.org/10.1038/ng.3667, 2016, ' The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals ', Nature Genetics, vol. 48, no. 10, pp. 1171-1184 . https://doi.org/10.1038/ng.3667, Nature genetics, 48(10), 1171-1184. Nature Publishing Group, NATURE GENETICS, Ehret, G B, Ferreira, T, Chasman, D I, Jackson, A U, Schmidt, E M, Johnson, T, Thorleifsson, G, Luan, J, Donnelly, L A, Kanoni, S, Petersen, A-K, Pihurl, V, Strawbridge, R J, Shungin, D, Hughes, M F, Meirelles, O, Kaakinen, M, Bouatia-Naji, N, Kristiansson, K, Shah, S, Kleber, M E, Guo, X, Lyytikainen, L-P, Fava, C, Eriksson, N, Nolte, I M, Magnusson, P K, Salfati, E L, Rallidis, L S, Theusch, E, Smith, A J P, Folkersen, L, Witkowska, K, Pers, T H, Joehanes, R, Kim, S K, Lataniotis, L, Jansen, R, Johnson, A D, Warren, H, Kim, Y J, Zhao, W, Wu, Y, Tayo, B O, Bochud, M, Absher, D, Adair, L S, Amin, N, Arkingl, D E, Axelsson, T, Baldassarre, D, Balkau, B, Bandinelli, S, Barnes, M R, Barroso, I, Bevan, S, Bis, J C, Bjornsdottir, G, Boehnke, M, Boerwinkle, E, Bonnycastle, L L, Boomsma, D I, Bornstein, S R, Brown, M J, Burnier, M, Cabrera, C P, Chambers, J C, Chang, I-S, Cheng, C-Y, Chines, P S, Chung, R-H, Collins, F S, Connell, J M, Doring, A, Dallongeville, J, Danesh, J, de Faire, U, Delgado, G, Dominiczak, A F, Doney, A S F, Drenos, F, Edkins, S, Eicher, J D, Elosua, R, Enroth, S, Erdmann, J, Eriksson, P, Esko, T, Evangelou, E, Evans, A, Fai, T, Farra, M, Felixl, J F, Ferrieres, J, Ferrucci, L, Fornage, M, Forrester, T, Franceschinil, N, Franco, O H, Franco-Cereceda, A, Fraser, R M, Ganesh, S K, Gao, H, Gertow, K, Gianfagna, F, Gigante, B, Giulianini, F, Goe, A, Goodall, A H, Goodarzi, M, Gorski, M, Grassler, J, Groves, C J, Gudnason, V, Gyllensten, U, Hallmans, G, Hartikainen, A-L, Hassinen, M, Havulinna, A S, Hayward, C, Hercberg, S, Herzig, K-H, Hicks, A A, Hingorani, A D, Hirschhorn, J N, Hofmanl, A, Holmen, J, Holmen, O L, Hottenga, J-J, Howard, P, Hsiung, C A, Hunt, S C, Ikram, M A, Illig, T, Iribarren, C, Jensen, R A, Kahonen, M, Kang, H M, Kathiresan, S, Keating, B J, Khaw, K-T, Kim, Y K, Kim, E, Kivimaki, M, Klopp, N, Kolovou, G, Komulainen, P, Kooner, J S, Kosova, G, Krauss, R M, Kuh, D, Kutalik, Z, Kuusisto, J, Kvaloy, K, Lakka, T A, Lee, N R, Lee, I-T, Lee, W-J, Levy, D, Li, X, Liang, K-W, Lin, H, Lin, L, Lindstrom, J, Lobbens, S, Mannisto, S, Muller, G, Muller-Nurasyid, M, Mach, F, Markus, H S, Marouli, E, McCarthy, M I, McKenzie, C A, Meneton, P, Menni, C, Metspalu, A, Mijatovic, V, Moilanen, L, Montasser, M E, Morris, A D, Morrison, A C, Mulas, A, Nagaraja, R, Narisu, N, Nikus, K, O'Donnell, C J, O'Reilly, P F, Ong, K K, Paccaud, F, Palmer, C D, Parsa, A, Pedersen, N L, Penninx, B W, Perola, M, Peters, A, Poulter, N, Pramstaller, P P, Psaty, B M, Quertermous, T, Rao, D C, Rasheed, A, Rayner, N W, Renstrom, F, Rettig, R, Rice, K M, Roberts, R, Rose, L M, Rossouw, J, Samani, N J, Sanna, S, Saramies, J, Schunkert, H, Sebert, S, Sheu, W H-H, Shin, Y-A, Sim, X, Smit, J H, Smith, A V, Sosa, M X, Spector, T D, Stancakova, A, Stanton, A V, Stirrups, K E, Stringham, H M, Sundstrom, J, Swift, A J, Syvanen, A-C, Tai, E-S, Tanaka, T, Tarasov, K V, Teumer, A, Thorsteinsdottir, U, Tobin, M D, Tremoli, E, Uitterlinden, A G, Uusitupa, M, Vaez, A, Vaidya, D, van Duijn, C M, van Iperen, E P A, Vasan, R S, Verwoert, G C, Virtamo, J, Vitart, V, Voight, B F, Vollenweider, P, Wagner, A, Wain, L V, Wareham, N J, Watldns, H, Weder, A B, Westra, H J, Wilks, R, Wilsgaard, T, Wilson, J F, Wong, T Y, Yang, T-P, Yao, J, Yengo, L, Zhang, W, Zhao, J H, Zhu, X, Bovet, P, Cooper, R S, Mohlke, K L, Saleheen, D, Lee, J-Y, Elliott, P, Gierman, H J, Willer, C J, Franke, L, Hovingh, G K, Taylor, K D, Dedoussis, G, Sever, P, Wong, A, Lind, L, Assimes, T L, Njolstad, I, Schwarz, P E H, Langenberg, C, Snieder, H, Caulfield, M J, Melander, E, Laakso, M, Saltevo, J, Rauramaa, R, Tuomilehto, J, Ingelsson, E, Lehtimaki, T, Hveem, K, Palmas, W, Marz, W, Kumar, M, Salomaa, V, Chen, Y-D I, Rotter, J I, Froguel, P, Jarvelin, M-R, Lakatta, E G, Kuulasmaa, K, Franks, P W, Hamsten, A, Wichmann, H-E, Palmer, C N A, Stefansson, K, Ridker, P M, Loos, R J F, Chalcravarti, A, Deloukas, P, Morris, A P, Newton-Cheh, C & Munroe, P B 2016, ' The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals ', Nature Genetics, vol. 48, no. 10, pp. 1171-1184 . https://doi.org/10.1038/ng.3667, Nature genetics, vol. 48, no. 10, pp. 1171-1184
- Accession number :
- edsair.doi.dedup.....8302f548fe724bc58e53e2bd329cb3c3