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Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health
Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health
- Source :
- Acta Diabetologica
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- East Asians appear to secrete less insulin than Caucasians following oral glucose suggesting that impaired insulin secretion is fundamental to the pathogenesis of type 2 diabetes [1]. Information about the secretion of the incretin hormones, GIP and GLP-1, dependent on duodenal glucose load [2], in East Asians is limited [3]. We have evaluated glycemic, insulinemic and incretin hormone responses to intraduodenal glucose in healthy Han Chinese. We studied eleven Han Chinese (HC) and eight Caucasian (C) healthy men; the latter included in a previous study [2]. Each subject attended following an overnight fast. A catheter, incorporating an infusion channel opening 12 cm beyond the pylorus, was inserted intranasally [2]. An IV cannula was placed in an antecubital vein. Intraduodenal (ID) glucose (25 g/100 mL) was infused at 4 kcal/min from t = 0 to 120 min. Blood was collected at t = 0, 15, 30, 45, 60, 90, 105 and 120 min for measurements of blood glucose, plasma insulin, GIP and GLP-1. Insulin secretion was estimated as the change in insulin divided by the change in glucose at 30 min (∆I0–30/∆G0–30). Insulin sensitivity was estimated as 1/fasting insulin. The disposition index (DIO) was calculated as ∆I0–30/∆G0–30X 1/fasting insulin. Unpaired Student’s t test was used in analysis. Han Chinese younger than Caucasians (24.8 ± 1.3 HC vs. 45.3 ± 3.8 C years, P
- Subjects :
- Adult
Blood Glucose
Male
endocrine system
medicine.medical_specialty
Duodenum
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Incretin
Gastric Inhibitory Polypeptide
Type 2 diabetes
White People
Pathogenesis
Young Adult
Endocrinology
Asian People
Diabetes mellitus
Internal medicine
Insulin Secretion
Ethnicity
Internal Medicine
medicine
Humans
Insulin
Infusions, Parenteral
Letter to the Editor
Glycemic
business.industry
General Medicine
Middle Aged
medicine.disease
Pylorus
Glucose
medicine.anatomical_structure
Health
Insulin Resistance
business
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 14325233 and 09405429
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Acta Diabetologica
- Accession number :
- edsair.doi.dedup.....83076a732cdd57acb19a37968388f6ee
- Full Text :
- https://doi.org/10.1007/s00592-014-0684-x