Back to Search Start Over

Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health

Ethnic disparities in insulin and glucose-dependent insulinotropic peptide (GIP) responses to intraduodenal glucose in health

Authors :
Michael Horowitz
Kylie Lange
Christopher K. Rayner
Chinmay S. Marathe
Michelle J. Bound
Karen L. Jones
Marathe, Chinmay S
Bound, Michelle
Lange, Kylie
Jones, Karen L
Rayner, Christopher K
Horowitz, Michael
Source :
Acta Diabetologica
Publication Year :
2014
Publisher :
Springer Science and Business Media LLC, 2014.

Abstract

East Asians appear to secrete less insulin than Caucasians following oral glucose suggesting that impaired insulin secretion is fundamental to the pathogenesis of type 2 diabetes [1]. Information about the secretion of the incretin hormones, GIP and GLP-1, dependent on duodenal glucose load [2], in East Asians is limited [3]. We have evaluated glycemic, insulinemic and incretin hormone responses to intraduodenal glucose in healthy Han Chinese. We studied eleven Han Chinese (HC) and eight Caucasian (C) healthy men; the latter included in a previous study [2]. Each subject attended following an overnight fast. A catheter, incorporating an infusion channel opening 12 cm beyond the pylorus, was inserted intranasally [2]. An IV cannula was placed in an antecubital vein. Intraduodenal (ID) glucose (25 g/100 mL) was infused at 4 kcal/min from t = 0 to 120 min. Blood was collected at t = 0, 15, 30, 45, 60, 90, 105 and 120 min for measurements of blood glucose, plasma insulin, GIP and GLP-1. Insulin secretion was estimated as the change in insulin divided by the change in glucose at 30 min (∆I0–30/∆G0–30). Insulin sensitivity was estimated as 1/fasting insulin. The disposition index (DIO) was calculated as ∆I0–30/∆G0–30X 1/fasting insulin. Unpaired Student’s t test was used in analysis. Han Chinese younger than Caucasians (24.8 ± 1.3 HC vs. 45.3 ± 3.8 C years, P

Details

ISSN :
14325233 and 09405429
Volume :
52
Database :
OpenAIRE
Journal :
Acta Diabetologica
Accession number :
edsair.doi.dedup.....83076a732cdd57acb19a37968388f6ee
Full Text :
https://doi.org/10.1007/s00592-014-0684-x