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PIK3CA Genotype and Treatment Decisions in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

PIK3CA Genotype and Treatment Decisions in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Authors :
Philippe L. Bedard
David W. Cescon
Source :
Journal of Clinical Oncology. 33:1318-1321
Publication Year :
2015
Publisher :
American Society of Clinical Oncology (ASCO), 2015.

Abstract

Genotyping of patient tumors has been rapidly incorporated into both clinical trials and clinical practice over the last several years, with the goal of advancing personalized or precision cancer medicine. The crux of these efforts is to identify actionable alterations— genetic changes that can be used to guide individualized treatment. Dramatic advances in sequencing technologies and DNA isolation methods now enable multiplex hotspot mutation testing or targeted exome se

Details

ISSN :
15277755 and 0732183X
Volume :
33
Database :
OpenAIRE
Journal :
Journal of Clinical Oncology
Accession number :
edsair.doi.dedup.....831195254f20ee3c03fdadd033f7f9a6
Full Text :
https://doi.org/10.1200/jco.2014.59.3160