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Microelements as risk factors for cancer of the lung and larynx

Microelements as risk factors for cancer of the lung and larynx

Authors :
Anna Jakubowska
Katrzyna Jaworska-Bieniek
Katarzyna Durda
Marcin Lener
Jan Lubinski
Mieczysław Sulikowski
Grzegorz Sukiennicki
Satish Gupta
Magdalena Muszyńska
Tomasz Grodzki
Janusz Wójcik
Ping Sun
Tadeusz Dębniak
Jakub Lubiński
Cezary Cybulski
Piotr Woloszczyk
Elżbieta Jaworowska
Steven A. Narod
Source :
Hereditary Cancer in Clinical Practice, Hereditary Cancer in Clinical Practice, Vol 10, Iss Suppl 4, p A2 (2012)
Publication Year :
2012
Publisher :
Springer Science and Business Media LLC, 2012.

Abstract

Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer. Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.7 µg/l for their matched controls (p 80 µg/l) was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.24 (95% CI 0.10 to 0.59; p = 0.002) for laryngeal cancer. In four selenoproteins studied here we found a modest associations of genetic variants in GPX1 and GPX4 with lung and TXNRD2 with laryngeal cancer risk. We analyzed iron (Fe) level in serum of 77 lung cancer patients and 77 matched controls. We did not find difference in mean Fe level between cases and controls (1053.05 µg/l and 1059.39 µg/l). However, we found that Fe level in the lowest and highest quartiles was associated with a significant lung risk enhancement when compared to a serum Fe level in the middle quartiles (OR 0.3, p 0.02). We also observed that the relationship between the level of Fe and Se could be an important factor for lung cancer risk.

Details

ISSN :
18974287
Volume :
10
Database :
OpenAIRE
Journal :
Hereditary Cancer in Clinical Practice
Accession number :
edsair.doi.dedup.....83209d0e5abc68713af9e0abfd842e18
Full Text :
https://doi.org/10.1186/1897-4287-10-s4-a2