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Microelements as risk factors for cancer of the lung and larynx
Microelements as risk factors for cancer of the lung and larynx
- Source :
- Hereditary Cancer in Clinical Practice, Hereditary Cancer in Clinical Practice, Vol 10, Iss Suppl 4, p A2 (2012)
- Publication Year :
- 2012
- Publisher :
- Springer Science and Business Media LLC, 2012.
-
Abstract
- Selenium deficiency has been suggested by several studies to be associated with cancer risk. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 86 cases of lung cancer, 87 cases of laryngeal cancer and an equal number of healthy controls. We studied the serum level of selenium and genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15) and the odds of being diagnosed with lung or laryngeal cancer. Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.7 µg/l for their matched controls (p 80 µg/l) was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.24 (95% CI 0.10 to 0.59; p = 0.002) for laryngeal cancer. In four selenoproteins studied here we found a modest associations of genetic variants in GPX1 and GPX4 with lung and TXNRD2 with laryngeal cancer risk. We analyzed iron (Fe) level in serum of 77 lung cancer patients and 77 matched controls. We did not find difference in mean Fe level between cases and controls (1053.05 µg/l and 1059.39 µg/l). However, we found that Fe level in the lowest and highest quartiles was associated with a significant lung risk enhancement when compared to a serum Fe level in the middle quartiles (OR 0.3, p 0.02). We also observed that the relationship between the level of Fe and Se could be an important factor for lung cancer risk.
- Subjects :
- medicine.medical_specialty
GPX1
Pathology
Lung
lcsh:QH426-470
business.industry
Cancer
Odds ratio
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
lcsh:RC254-282
Gastroenterology
lcsh:Genetics
medicine.anatomical_structure
Oncology
Quartile
Selenium deficiency
Internal medicine
Meeting Abstract
Genotype
medicine
Lung cancer
business
Genetics (clinical)
Subjects
Details
- ISSN :
- 18974287
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Hereditary Cancer in Clinical Practice
- Accession number :
- edsair.doi.dedup.....83209d0e5abc68713af9e0abfd842e18
- Full Text :
- https://doi.org/10.1186/1897-4287-10-s4-a2