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Melatonin controversies, an update
- Source :
- Journal of Pineal Research
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Melatonin was discovered more than 60 years ago. Since then, several seminal discoveries have allowed us to define its function as a neuroendocrine hormone and its molecular targets in mammals and many other species. However, many fundamental issues have not yet been solved such as the subcellular localization of melatonin synthesis and the full spectrum of its molecular targets. In addition, a considerable number of controversies persist in the field, mainly concerning how many functions melatonin has. Altogether, this illustrates how "immature" the field still is. The intention of this opinion article is to note the controversies and limitations in the field, to initiate a discussion and to make proposals/guidelines to overcome them and move the field forward.
- Subjects :
- 0301 basic medicine
Cognitive science
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Antioxidants
COVID-19 Drug Treatment
Melatonin
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Endocrinology
Alzheimer Disease
Political science
Molecular targets
medicine
Animals
Humans
Neuroendocrine hormone
Melatonin synthesis
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 1600079X and 07423098
- Database :
- OpenAIRE
- Journal :
- Journal of Pineal Research
- Accession number :
- edsair.doi.dedup.....835c869726979764a8c12b079a111c75
- Full Text :
- https://doi.org/10.1111/jpi.12702