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Bioengineered Magnetoferritin Nanoprobes for Single-Dose Nuclear-Magnetic Resonance Tumor Imaging
- Source :
- ACS Nano. 10:4184-4191
- Publication Year :
- 2016
- Publisher :
- American Chemical Society (ACS), 2016.
-
Abstract
- Despite all the advances in multimodal imaging, it remains a significant challenge to acquire both magnetic resonance and nuclear imaging in a single dose because of the enormous difference in sensitivity. Indeed, nuclear imaging is almost 10(6)-fold more sensitive than magnetic resonance imaging (MRI); thus, repeated injections are generally required to obtain sufficient MR signals after nuclear imaging. Here, we show that strategically engineered magnetoferritin nanoprobes can image tumors with high sensitivity and specificity using SPECT and MRI in living mice after a single intravenous injection. The magnetoferritin nanoprobes composed of (125)I radionuclide-conjugated human H-ferritin iron nanocages ((125)I-M-HFn) internalize robustly into cancer cells via a novel tumor-specific HFn-TfR1 pathway. In particular, the endocytic recycling characteristic of TfR1 transporters solves the nuclear signal blocking issue caused by the high dose nanoprobes injected for MRI, thus enabling simultaneous functional and morphological tumor imaging without reliance on multi-injections.
- Subjects :
- Magnetic Resonance Spectroscopy
Materials science
Nuclear imaging
Iron
Contrast Media
General Physics and Astronomy
Endocytic recycling
02 engineering and technology
010402 general chemistry
01 natural sciences
Iodine Radioisotopes
Nanocages
Nuclear magnetic resonance
Antigens, CD
Cell Line, Tumor
Receptors, Transferrin
medicine
Animals
Humans
General Materials Science
Magnetite Nanoparticles
Tomography, Emission-Computed, Single-Photon
Multimodal imaging
Tumor imaging
Mice, Inbred BALB C
medicine.diagnostic_test
Optical Imaging
Magnetoferritin
General Engineering
Oxides
Magnetic resonance imaging
021001 nanoscience & nanotechnology
Magnetic Resonance Imaging
0104 chemical sciences
Apoferritins
Heterografts
Female
Radiopharmaceuticals
0210 nano-technology
Subjects
Details
- ISSN :
- 1936086X and 19360851
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- ACS Nano
- Accession number :
- edsair.doi.dedup.....8373049cf50ce5745d42ee9a3c614f4a