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Clinical activity of eribulin in advanced desmoplastic small round-cell tumor
- Source :
- Anti-cancer drugs. 28(9)
- Publication Year :
- 2017
-
Abstract
- Desmoplastic small round-cell tumor is a rare but highly aggressive tumor occurring mainly in adolescents and young adults. Prolonged progression-free survival has been documented in patients who have undergone aggressive multimodality therapy - that is, multiagent intensive chemotherapy, debulking surgery, and radiation therapy. Eribulin is a microtubule-dynamics inhibitor, and it has recently been shown to be active in liposarcomas. In preclinical models, eribulin activities have also been shown to occur in Ewing's sarcoma cell lines, rhabdomyosarcomas and osteosarcomas. In this study, we report three cases of male patients suffering from desmoplastic small round-cell tumor and the clinical response to eribulin in two of them.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
Cancer Research
medicine.medical_specialty
Desmoplastic small-round-cell tumor
medicine.medical_treatment
Intensive chemotherapy
Multimodality Therapy
Desmoplastic Small Round Cell Tumor
Disease-Free Survival
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
Pharmacology (medical)
Young adult
Furans
Peritoneal Neoplasms
Pharmacology
business.industry
Ketones
medicine.disease
Debulking
Radiation therapy
Pancreatic Neoplasms
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Sarcoma
business
Eribulin
Subjects
Details
- ISSN :
- 14735741
- Volume :
- 28
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Anti-cancer drugs
- Accession number :
- edsair.doi.dedup.....83925310c1bf6cd4600bd58e7cc7079f