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Oxidative Stress Is Reduced in Wistar Rats Exposed to Smoke from Tobacco and Treated with Specific Broad-Band Pulse Electromagnetic Fields
- Source :
- Archives of Biological Sciences, Archives of Biological Sciences, Vol 61, Iss 3, Pp 353-366 (2009)
- Publication Year :
- 2009
-
Abstract
- There have been a number of attempts to reduce the oxidative radical burden of tobacco. A recently patented technology, pulse electromagnetic technology, has been shown to induce differential action of treated tobacco products versus untreated products on the production of reactive oxygen species (ROS) in vivo. In a 90-day respiratory toxicity study, Wistar rats were exposed to cigarette smoke from processed and unprocessed tobacco and biomarkers of oxidative stress were compared with pathohistological analysis of rat lungs. Superoxide dismutase (SOD) activity was decreased in a dose-dependent manner to 81% in rats exposed to smoke from normal cigarettes compared to rats exposed to treated smoke or the control group. These results correspond to pathohistological analysis of rat lungs, in which those rats exposed to untreated smoke developed initial signs of emphysema, while rats exposed to treated smoke showed no pathology, as in the control group. The promise of inducing an improved health status in humans exposed to smoke from treated cigarettes merits further investigation.
- Subjects :
- Pharmacology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Tobacco smoke
Toxicology
Superoxide dismutase
03 medical and health sciences
0302 clinical medicine
In vivo
broad-band electromagnetic waves
Medicine
Respiratory system
lcsh:QH301-705.5
030304 developmental biology
Smoke
chemistry.chemical_classification
0303 health sciences
Reactive oxygen species
biology
business.industry
3. Good health
emphysema
lcsh:Biology (General)
030228 respiratory system
chemistry
Oxidative stress
Toxicity
biology.protein
General Agricultural and Biological Sciences
business
tobacco smoke
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Archives of Biological Sciences, Archives of Biological Sciences, Vol 61, Iss 3, Pp 353-366 (2009)
- Accession number :
- edsair.doi.dedup.....83a755a5a8ae2a73d2b716a49a6d5824