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Prevalence of asymptomatic coronary disease in fibrosing idiopathic interstitial pneumonias
- Source :
- European Journal of Radiology. 84:163-171
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Background Because of growing body of interest on the association between fibrosing idiopathic interstitial pneumonias (f-IIP) and ischaemic heart disease, we initiated this prospective study to evaluate the prevalence of asymptomatic coronary artery disease (CAD) in patients with f-IIP. Methods Forty-two patients with f-IIP underwent noninvasive screening for CAD that included (a) a chest CT examination enabling calculation of the coronary artery calcium (CAC) score, then depiction of coronary artery stenosis; and (b) stress myocardial perfusion scintigraphy (MPS). Patients with significant coronary abnormalities, defined by a CAC score >400 or coronary artery stenosis >50% at CT and/or perfusion defect >5% at MPS, were referred to the cardiologist. Coronary angiography was indicated in presence of a perfusion defect >10% at MPS or significant left main or proximal left anterior descending stenosis whatever MPS findings. Results Combining CT and MPS, significant abnormalities were detected in 32/42 patients (76%). The cardiologist: (a) did not consider further investigation in 21 patients (CT abnormalities but no ischaemia at MPS: 12/21; false-positive findings at MPS: 3/21; poor respiratory condition: 6/21); (b) proceeded to coronary angiography in 11 patients which confirmed significant stenoses in 5 patients (5/42; 12%). In the worst-case-scenario (i.e., inclusion of 6 patients with significant coronary artery abnormalities who were not investigated due to poor respiratory condition), the prevalence of CAD reached 26% (11/42). Conclusion In the studied population of patients with f-IIP, asymptomatic CAD ranged between 12% and 26%.
- Subjects :
- Male
medicine.medical_specialty
Population
Comorbidity
Coronary Artery Disease
Coronary Angiography
Asymptomatic
Coronary artery disease
Idiopathic pulmonary fibrosis
medicine.artery
Internal medicine
Prevalence
medicine
Humans
Radiology, Nuclear Medicine and imaging
Idiopathic Interstitial Pneumonias
Prospective Studies
education
Idiopathic interstitial pneumonia
Aged
education.field_of_study
business.industry
Coronary Stenosis
nutritional and metabolic diseases
General Medicine
medicine.disease
Coronary arteries
Stenosis
medicine.anatomical_structure
Right coronary artery
Cardiology
Female
Radiology
medicine.symptom
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 0720048X
- Volume :
- 84
- Database :
- OpenAIRE
- Journal :
- European Journal of Radiology
- Accession number :
- edsair.doi.dedup.....83bbb833952211f9212ecd2e49943343