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Both four-dimensional computed tomography and four-dimensional cone beam computed tomography under-predict lung target motion during radiotherapy
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- BACKGROUND AND PURPOSE: To test the hypothesis that 4DCT and 4DCBCT-measured target motion ranges predict target motion ranges during lung cancer SABR. MATERIALS AND METHODS: Ten lung SABR patients were implanted with Calypso beacons. 4DCBCT was reconstructed for 29 fractions (1-4fx/patient) from a 1 min CBCT scan. The beacon centroid motion segmented for all 4DCT and 4DCBCT bins was compared with the real-time imaging and treatment beacon centroid ("target") motion range (4SDs) for each fraction. We tested the hypotheses that (1) 4DCT and 4CBCT predict treatment motion range and (2) there is no difference between 4DCT and 4DCBCT for predicting treatment motion range. Phase-wise root-mean-square errors (RMSEs) between imaging and treatment motion and reconstructed motion (4DCT, 4DCBCT) were calculated. Relationships between motion ranges in 4DCT and 4DCBCT and imaging and treatment motion ranges were investigated for the superior-inferior (SI), left-right (LR) and anterior-posterior (AP) directions. Baseline drifts and amplitude variability were investigated as potential factors leading to motion misrepresentation. RESULTS: SI 4DCT, 4DCBCT, imaging and treatment motion ranges were 6.3 ± 3.6 mm, 7.1 ± 4.5 mm, 11.1 ± 7.5 mm and 10.9 ± 6.9 mm, respectively. Similar 4DCT and 4DCBCT under-predictions were observed in the LR and AP directions. Hypothesis (1) was rejected (p
- Subjects :
- Cone beam computed tomography
Lung Neoplasms
medicine.medical_treatment
Motion (geometry)
SABR volatility model
Radiosurgery
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Treatment targets
motion management
Predictive Value of Tests
medicine
Humans
Radiology, Nuclear Medicine and imaging
Computer Simulation
Four-Dimensional Computed Tomography
Lung
Physics
business.industry
Radiotherapy Planning, Computer-Assisted
Centroid
Hematology
Cone-Beam Computed Tomography
Radiation therapy
Amplitude
Oncology
030220 oncology & carcinogenesis
Respiratory Mechanics
Nuclear medicine
business
Algorithms
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....8409eb55cfb11ffb412f6ba27b22f646