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Environmental factors and their timing in adult-onset multiple sclerosis

Environmental factors and their timing in adult-onset multiple sclerosis

Authors :
Sreeram V. Ramagopalan
Adam E. Handel
George C. Ebers
Gavin Giovannoni
Publication Year :
2016
Publisher :
Macmillan Publishers Ltd., 2016.

Abstract

Multiple sclerosis (MS) is a common, complex neurological disease. Epidemiological data implicate both genetic and environmental factors in the etiology of MS, with various factors interacting with one another. Environmental exposures might occur long before the disease becomes clinically evident, as suggested by the wide range in onset age. In this Review, we examine the key time periods during which the environment might contribute to MS susceptibility, as well as the potential environmental factors involved. Understanding the nature of environmental influences in MS is highly relevant to the development of public health measures that are aimed at preventing this debilitating disease.

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....840ec1a6ed0afe03c07507697b2c0f7a
Full Text :
https://doi.org/10.1038/nrneurol.2010.1