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Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60–102 Years
- Source :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, The journals of gerontology. Series A, Biological sciences and medical sciences, 75(9), 1609-1617. Oxford University Press, The journals of gerontology. Series A : Biological sciences and medical sciences, 75(9), 1609-1617. Oxford University Press, Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 75(9), 1609-1617. Oxford University Press, Legdeur, N, Tijms, B M, Konijnenberg, E, den Braber, A, ten Kate, M, Sudre, C H, Tomassen, J, Badissi, M, Yaqub, M, Barkhof, F, van Berckel, B N, Boomsma, D I, Scheltens, P, Holstege, H, Maier, A B & Visser, P J 2020, ' Associations of Brain Pathology Cognitive and Physical Markers With Age in Cognitively Normal Individuals Aged 60-102 Years ', The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 75, no. 9, pp. 1609-1617 . https://doi.org/10.1093/gerona/glz180, Legdeur, N, Tijms, B M, Konijnenberg, E, den Braber, A, Ten Kate, M, Sudre, C H, Tomassen, J, Badissi, M, Yaqub, M, Barkhof, F, van Berckel, B N, Boomsma, D I, Scheltens, P, Holstege, H, Maier, A B & Visser, P J 2020, ' Associations of brain pathology, cognitive and physical markers with age in cognitively normal individuals aged 60-102 years ', The journals of gerontology. Series A : Biological sciences and medical sciences, vol. 75, no. 9, pp. 1609-1617 . https://doi.org/10.1093/gerona/glz180
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- The prevalence of brain pathologies increases with age and cognitive and physical functions worsen over the lifetime. It is unclear whether these processes show a similar increase with age. We studied the association of markers for brain pathology cognitive and physical functions with age in 288 cognitively normal individuals aged 60–102 years selected from the cross-sectional EMIF-AD PreclinAD and 90+ Study at the Amsterdam UMC. An abnormal score was consistent with a score below the 5th percentile in the 60- to 70-year-old individuals. Prevalence of abnormal scores was estimated using Generalized Estimating Equations (GEE) models. The prevalence of abnormal handgrip strength, the Digit Symbol Substitution Test, and hippocampal volume showed the fastest increase with age and abnormal MMSE score, muscle mass, and amyloid aggregation the lowest. The increase in prevalence of abnormal markers was partly dependent on sex, level of education, and amyloid aggregation. We did not find a consistent pattern in which markers of brain pathology cognitive and physical processes became abnormal with age.
- Subjects :
- Male
Netherlands Twin Register (NTR)
Aging
Pathology
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Cross-sectional study
Hippocampus
Gee
MUSCLE STRENGTH
AcademicSubjects/MED00280
0302 clinical medicine
030212 general & internal medicine
Generalized estimating equation
Human aging
Aged, 80 and over
Hand Strength
medicine.diagnostic_test
DEMENTIA
Age Factors
Brain
Cognition
Middle Aged
Mental Status and Dementia Tests
PREVALENCE
ALZHEIMERS-DISEASE
Educational Status
Female
SEX
Cognitive function
medicine.medical_specialty
Mechanisims of Cognitve and Neurological Aging
APOE EPSILON-4
03 medical and health sciences
Sex Factors
Hand strength
medicine
Humans
Dementia
Muscle, Skeletal
OLDER-ADULTS
Aged
Amyloid beta-Peptides
Mini–Mental State Examination
business.industry
PERFORMANCE
medicine.disease
TEMPORAL RELATIONSHIP
Cross-Sectional Studies
HANDGRIP STRENGTH
Brain aging
Cognitive Aging
Digit symbol substitution test
AcademicSubjects/SCI00960
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 1758535X and 10795006
- Volume :
- 75
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Accession number :
- edsair.doi.dedup.....84106b7516d5524d7d4179097c2b2697