Back to Search
Start Over
Clinical predictors of long COVID-19 and phenotypes of mild COVID-19 at a tertiary care centre in India
- Source :
- Drug Discoveries & Therapeutics. 15:156-161
- Publication Year :
- 2021
- Publisher :
- International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA), 2021.
-
Abstract
- A variable proportion of patients develop persistent/prolonged symptoms of Coronavirus Disease 2019 (COVID-19) infection (long COVID). We aimed to study the clinical predictors of persistent symptoms in patients with mild COVID-19 at 30 days post discharge (long COVID-19). We also tried to identify symptom clusters among mild COVID-19 patients. Fifty-seven patients admitted at a tertiary care centre after a positive RT-PCR report over a period of 2 months, were enrolled in the study. Details of presentation, history of illness, laboratory investigations and disease outcomes were recorded from documented medical records and discharge slip. The patients were contacted (telephonically) at 30 days after discharge and enquired regarding persistent symptoms, if any. Follow up data at 30 days post-discharge was available for 53 patients. Among them, the most common persistent symptom was fatigue (22.6%), followed by cough (9.4%) and myalgias (7.5%). There was a significant association of persistent symptoms with diarrhoea at presentation [OR 14.26 (95% CI 2.30-142.47; p = 0.009] and gap between symptom onset and admission [OR 1.40 (95% CI 1.08-1.93; p = 0.020] on multivariate logistic regression analysis. On cluster analysis, three phenotypes of mild COVID-19 were identified, which may have implications on monitoring and management. There appears to be a positive association of diarrhoea as a presenting manifestation and gap between symptom onset and admission with the persistence of symptoms classified as long COVID-19, even in mild illness. We also identified multiple phenotypes of mild COVID-19 illness, which warrant further exploration.
- Subjects :
- Adult
Male
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Post discharge
India
Logistic regression
Tertiary care
Tertiary Care Centers
Young Adult
Internal medicine
Humans
Medicine
Pharmacology (medical)
In patient
General Pharmacology, Toxicology and Pharmaceutics
Young adult
SARS-CoV-2
business.industry
Medical record
COVID-19
General Medicine
Middle Aged
After discharge
Patient Discharge
Time and Motion Studies
Female
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 1881784X and 18817831
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Drug Discoveries & Therapeutics
- Accession number :
- edsair.doi.dedup.....841ae5a60a8935f9998ab7894d648284