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Inflammatory diets are associated with lower total iron binding capacity in sera of young adults
- Source :
- International Journal for Vitamin and Nutrition Research. 93:9-17
- Publication Year :
- 2023
- Publisher :
- Hogrefe Publishing Group, 2023.
-
Abstract
- Abstract. Chronic, systemic inflammation, which is associated with obesity and numerous other diseases, impairs iron status by increasing hepcidin concentration. Inflammation also decreases the concentration of transferrin, the main iron transport protein and a negative acute phase protein, which is indirectly assessed by measuring total iron binding capacity (TIBC). However, the contribution of diet-induced inflammation has not been studied. Data from two studies, namely Diet and Inflammation and Selenium and Inflammation Studies (total n=98) were used to assess the associations among Dietary Inflammatory Index (DII®) scores derived from three-day dietary records, body mass index (BMI=weight[kg]/height[m]2), inflammatory and hematological markers among young adults with normal-weight, overweight or obesity. Subjects’ diets were also categorized as less inflammatory diets (LID) and inflammatory diets (ID) using cluster analysis. Independent t-test and regression analyses were used to assess associations in the data. Intakes of iron, proteins, fat, fiber, and calories were higher in the LID group compared to the ID group (p0.05). Higher DII score was associated with increasing CRP (β+SE=0.23+0.07, p=0.002) and lower TIBC (β+SE=−8.46+3.44, p=0.02), independent of BMI category. The LID diet was associated with higher TIBC (β+SE=29.87+10.75, p=0.007) compared to the ID diet. In conclusion, inflammatory diets may impair iron status by reducing the iron binding capacity of transferrin.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Calorie
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
Systemic inflammation
03 medical and health sciences
0302 clinical medicine
Hepcidin
Total iron-binding capacity
Internal medicine
Medicine
chemistry.chemical_classification
030109 nutrition & dietetics
Nutrition and Dietetics
biology
medicine.diagnostic_test
business.industry
C-reactive protein
Acute-phase protein
General Medicine
Endocrinology
chemistry
Transferrin
biology.protein
medicine.symptom
business
Body mass index
Subjects
Details
- ISSN :
- 16642821 and 03009831
- Volume :
- 93
- Database :
- OpenAIRE
- Journal :
- International Journal for Vitamin and Nutrition Research
- Accession number :
- edsair.doi.dedup.....845acbc370c4bf78e97ee6a4b2cbe1d4