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Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas
- Source :
- Diagnostic Pathology
- Publication Year :
- 2015
- Publisher :
- Springer Science and Business Media LLC, 2015.
-
Abstract
- Background Medulloblastoma is a malignant, invasive embryonal tumor of the cerebellum and accounts for 20% of intracranial tumors in children. QSOX1, whose functions include formation of disulphide bridges, which are needed for correct protein folding and stability, formation of the extracellular matrix, regulation of the redox status and cell cycle control, appears to be involved in apoptosis in pathological states such as cancer. Thus, the aim of this study was to investigate the immunohistochemical expression of QSOX1 in medulloblastomas and nonneoplastic cerebellum. Methods Histology blocks of pediatric medulloblastomas were separated and two representative areas of the tumors and non-neoplastic cerebellum samples were used to construct tissue microarrays (TMAs) that were stained with an anti-QSOX1 antibody, and the slides were read using image analysis software. Results QSOX1 immunoexpression was observed in the non-neoplastic cerebellum samples and the medulloblastoma samples. There was no statistically significant relationship between QSOX1 immunopositivity in the medulloblastoma samples and the clinical and pathological variables. Conclusions Although QSOX1 did not prove useful for stratifying patients into risk groups, tumor cells and the fibrillar extracellular matrix were positive for this marker, indicating that this enzyme may be involved in the pathogenesis of medulloblastoma. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1822040654139436
- Subjects :
- Pathology
medicine.medical_specialty
Histology
Adolescent
Apoptosis
Biology
Pathology and Forensic Medicine
Pathogenesis
Extracellular matrix
Cell Line, Tumor
QSOX1
medicine
Humans
Oxidoreductases Acting on Sulfur Group Donors
Cerebellar Neoplasms
Child
Medulloblastoma
Tissue microarray
Research
Infant
Sulfhydryl oxidase
Cancer
Cerebellar Neoplasm
General Medicine
medicine.disease
Immunohistochemistry
Extracellular Matrix
Immunohistochemical expression
Gene Expression Regulation, Neoplastic
Pediatric medulloblastomas
Child, Preschool
Subjects
Details
- ISSN :
- 17461596
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Diagnostic Pathology
- Accession number :
- edsair.doi.dedup.....845ba5d098c846b0e63cb868daee916e