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Sesquiterpenoids from the leaves of Sarcandra glabra
- Source :
- Chinese Journal of Natural Medicines. 20:215-220
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Sarglanoids A–F, six new sesquiterpenoids belonging to eudesmane ( 1 – 5 ) and eremophilane ( 6 ) types, were isolated from the leaves of Sarcandra glabra, a famous traditional Chinese medicine (TCM). Their structures including absolute configurations were elucidated through extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Thereinto, compounds 1 – 2 were rare N-containing eudesmane-type sesquiterpenoids. Compound 3 exhibited inhibitory activity against nitric oxide (NO) production in lipopolysaccharides (LPS)-induced RAW 264.7 cells with IC50 values at 20.00 ± 1.30 μM. This research provides scientific basis for sesquiterpenoids as the medicinal material foundation of S. glabra.
Details
- ISSN :
- 18755364
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- Chinese Journal of Natural Medicines
- Accession number :
- edsair.doi.dedup.....8463cca33fc5069915f1b3e0d12e249f