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Pluronic lecithin organogel of 5-aminosalicylic acid for wound healing
- Source :
- Drug Development and Industrial Pharmacy. 44:1650-1658
- Publication Year :
- 2018
- Publisher :
- Informa UK Limited, 2018.
-
Abstract
- 5-Aminosalicylic acid (5-ASA) is an aminosalicylate anti-inflammatory drug, which is also known as mesalazine or mesalamine. Currently employed in treating inflammatory bowel disease, ulcerative colitis, inflamed anus or rectum, and maintain remission in Crohn's disease. Evidence from the researchers highlighted its significant re-epithelization in allergic asthma, aphthous, and gastric ulcerative conditions. The objective of the study was to formulate the pluronic lecithin organogel (PLO) containing 5-ASA and evaluate its wound-healing ability in a full thickness excision wound rat model. The data obtained from in silico docking studies revealed 5-ASA is having an affinity towards the transforming growth factor-beta (TGF-β) specifically towards beta1. Among various formulations prepared (F1 to F8), F1, and F6 have shown a maximum in vitro drug release with optimum pH and viscosity. From MTT assay it was found that selected PLO formulations showed no toxicity and enhanced cell proliferation in HaCaT cell lines. In vivo wound-healing studies in albino Wistar rats has revealed that PLO accelerates wound closure and reepithelization to the statistically significant level on day 3 (p .05) in comparison with untreated wounds. In conclusion, the overall results suggest that 5-ASA PLO gel is a potential therapeutic option for the treatments of wounds, however, further studies are highly warrened to determine the various mechanisms of 5-ASA in regulating the cell migration and reepithelization in wound healing to outspread its use in clinics.
- Subjects :
- Male
0301 basic medicine
Drug
food.ingredient
Aminosalicylic acid
media_common.quotation_subject
Pharmaceutical Science
Poloxamer
Pharmacology
Inflammatory bowel disease
Lecithin
Aminosalicylate
Cell Line
Surface-Active Agents
03 medical and health sciences
chemistry.chemical_compound
food
Mesalazine
Cell Movement
Lecithins
Drug Discovery
medicine
Animals
Humans
Mesalamine
media_common
Wound Healing
business.industry
Anti-Inflammatory Agents, Non-Steroidal
Organic Chemistry
medicine.disease
digestive system diseases
Rats
030104 developmental biology
chemistry
Female
Rabbits
Wound healing
business
Gels
Subjects
Details
- ISSN :
- 15205762 and 03639045
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Drug Development and Industrial Pharmacy
- Accession number :
- edsair.doi.dedup.....84665fc310e7964ed97f1fa86f51403b