Back to Search
Start Over
Anti-inflammatory Therapies for Cardiovascular Disease: Signaling Pathways and Mechanisms
- Source :
- Revista Española de Cardiología (English Edition). 72:767-773
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Cardiovascular diseases (CVD) are the clinical manifestation of atherosclerosis, a chronic inflammatory disease promoted by several risk factors such as dyslipidemia, type 2 diabetes mellitus, hypertension, and smoking. Acute CVD events are the result of an unresolved inflammatory chronic state that promotes the rupture of unstable plaque lesions. Of note, the existing intensive therapies modify risk factors but do not prevent life-threatening recurrent ischemic events in high-risk patients, who have a residual inflammatory risk displayed by increased C-reactive protein (CRP) levels. Better understanding of the role of innate and adaptive immunity in plaque development and rupture has led to intensive investigation of anti-inflammatory strategies for CVD. Some of them are being tested in specific clinical trials and use lower doses of existing medications originally developed for other inflammatory diseases such as rheumatoid arthritis and psoriasis, which have high CVD risk. Other investigations are retrospective and meta-analyses of existing clinical trials that evaluate the incidence of CVD in these inflammatory diseases. Others are based on preclinical testing such as vaccines. In this article, we summarize the main anti-inflammatory strategies and associated molecular mechanisms that are being evaluated in preclinical or clinical CVD studies.
- Subjects :
- Inflammation
business.industry
medicine.medical_treatment
Anti-Inflammatory Agents
Type 2 Diabetes Mellitus
General Medicine
Disease
030204 cardiovascular system & hematology
medicine.disease
Bioinformatics
Acquired immune system
Clinical trial
03 medical and health sciences
C-Reactive Protein
0302 clinical medicine
Cytokine
Cardiovascular Diseases
Psoriasis
Rheumatoid arthritis
medicine
Humans
business
Biomarkers
Dyslipidemia
Signal Transduction
Subjects
Details
- ISSN :
- 18855857
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Revista Española de Cardiología (English Edition)
- Accession number :
- edsair.doi.dedup.....84c228bac689386c450b7c0565144b1f
- Full Text :
- https://doi.org/10.1016/j.rec.2019.03.007