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O-GlcNAcylation of BMAL1 regulates circadian rhythms in NIH3T3 fibroblasts

Authors :
Hunjin Luo
Wen-Juan Guan
Jia-Da Li
Yan-Tao Ma
Ziyao Wang
Chongfen Chen
Hua Zhang
Source :
Biochemical and biophysical research communications. 431(3)
Publication Year :
2012

Abstract

Various physiological processes and behaviors show a circadian rhythm of approximately 24 h, which is crucial in coordinating internal metabolic processes and environmental signals. Post-translational modifications play an important role in regulating circadian core proteins. In this study, we demonstrated that BMAL1 was modified with an O-linked β-N-acetylglucosamine (O-GlcNAc), which stabilized BMAL1 and enhanced its transcriptional activity. Conversely, inhibition of O-GlcNAcylation resulted in inhibition of circadian rhythms of clock gene expression. Because O-GlcNAcylation is sensitive to the glucose level, such a modification may provide a new mechanism connecting metabolism with circadian rhythms.

Details

ISSN :
10902104
Volume :
431
Issue :
3
Database :
OpenAIRE
Journal :
Biochemical and biophysical research communications
Accession number :
edsair.doi.dedup.....84eb57dd3c2bb6ed82d299516bbfa3b3