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Theoretical and Experimental SHG Angular Intensity Patterns from Healthy and Proteolysed Muscles
- Source :
- Biophysical Journal, Biophysical Journal, 2013, 104 (9), pp.1959-68. ⟨10.1016/j.bpj.2013.02.047⟩, Biophysical Journal, Biophysical Society, 2013, 104 (9), pp.1959-68. ⟨10.1016/j.bpj.2013.02.047⟩
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- International audience; SHG angular intensity pattern (SHG-AIP) of healthy and proteolysed muscle tissues are simulated and imaged here for the first time to our knowledge. The role of the spatial distribution of second-order nonlinear emitters on SHG-AIP is highlighted. SHG-AIP with two symmetrical spots is found to be a signature of healthy muscle whereas SHG-AIP with one centered spot in pathological mdx muscle is found to be a signature of myofibrillar disorder. We also show that SHG-AIP provides information on the three-dimensional structural organization of myofibrils in physiological and proteolysed muscle. Our results open an avenue for future studies aimed at unraveling more complex physiological and pathological fibrillar tissues organization.
- Subjects :
- animal structures
Future studies
Biophysics
[SDV.BBM.BP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics
Biology
Models, Biological
01 natural sciences
010309 optics
Xenopus laevis
03 medical and health sciences
0103 physical sciences
Animals
Molecular Machines, Motors, and Nanoscale Biophysics
Muscle, Skeletal
030304 developmental biology
[SDV.IB] Life Sciences [q-bio]/Bioengineering
0303 health sciences
Microscopy, Confocal
Structural organization
Anatomy
Intensity (physics)
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics
Scanning Laser Polarimetry
Proteolysis
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Myofibril
Subjects
Details
- ISSN :
- 00063495 and 15420086
- Volume :
- 104
- Database :
- OpenAIRE
- Journal :
- Biophysical Journal
- Accession number :
- edsair.doi.dedup.....850b84145844d82745422090475b9f6f