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Effect of aging and acetyl-<scp>l</scp>-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria
- Source :
- FEBS Letters. 350:213-215
- Publication Year :
- 1994
- Publisher :
- Wiley, 1994.
-
Abstract
- The effect of aging and treatment with acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria was studied. It was found that the activity of both these mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl-l-carnitine almost completely reversed this effect. Changes in the mitochondrial cardiolipin content appear to be responsible for these effects of acetyl-l-carnitine.
- Subjects :
- Male
Aging
Biophysics
Mitochondrion
Biochemistry
Mitochondria, Heart
Cytochrome oxidase
Electron Transport Complex IV
chemistry.chemical_compound
Rat heart mitochondria
Structural Biology
Genetics
Cardiolipin
Acetyl-L-carnitine
Animals
Cytochrome c oxidase
Molecular Biology
Mitochondrial protein
Adenine nucleotide translocase
ADP translocase
biology
Temperature
Cell Biology
Rat heart
Molecular biology
Rats
Adenosine Diphosphate
Acetyl-l-carnitine
Kinetics
chemistry
biology.protein
ATP–ADP translocase
Acetylcarnitine
Mitochondrial ADP, ATP Translocases
Subjects
Details
- ISSN :
- 00145793
- Volume :
- 350
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....8513481db2345cffe311dfdb91897494