Back to Search Start Over

Prevalence and Factors Associated With Liver Fibrosis Among Adult HIV-Infected Patients Attending Urban and Rural Care Clinics in Uganda

Authors :
Gregory D. Kirk
Ponsiano Ocama
Rosalind Parkes-Ratanshi
Alex Karabarinde
Clara Wekesa
Jim Aizire
Eve Marie Benson
Wekesa, Clara [0000-0001-6064-237X]
Apollo - University of Cambridge Repository
Source :
Open Forum Infectious Diseases
Publication Year :
2020
Publisher :
Oxford University Press (OUP), 2020.

Abstract

Background Liver fibrosis is common among HIV-infected patients. Risk factors vary by location. Understanding this variation may inform prevention strategies. We compared the prevalence and correlates of liver fibrosis among HIV-infected patients attending care clinics in Uganda. Methods This was a cross-sectional study involving 2030 HIV-infected patients attending care clinics in urban and rural Uganda. Liver fibrosis was defined as liver stiffness measurement (LSM) >7.1 KPa. Proportions and correlates of liver fibrosis were assessed and compared using logistic regression stratified by gender and site. Results Prevalence of liver fibrosis was higher among participants in the rural clinic (15% vs 11%; P = .017). History of tobacco use (urban P = .022; rural P = .035) and serologic evidence of hepatitis C infection (HCV; urban P = .028; rural P = .03) was associated with liver fibrosis in all men. Elevated liver transaminases (urban P = .002; rural P = .028) and increasing age (urban P = .008; rural P = .052) were risk factors among all women. Tobacco use among women was only a risk factor in those attending the rural clinic (P = .003), and detectable HIV viral load (P = .002) for men in the urban clinic. Conclusions Liver fibrosis is prevalent among HIV-infected persons in Uganda. HIV viral suppression and avoiding tobacco may be strategies to prevent liver fibrosis and cancer risk.

Details

ISSN :
23288957
Volume :
7
Database :
OpenAIRE
Journal :
Open Forum Infectious Diseases
Accession number :
edsair.doi.dedup.....85192a5f482f153b6a140aaffc7e1d8e
Full Text :
https://doi.org/10.1093/ofid/ofaa483