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Prevalence and Factors Associated With Liver Fibrosis Among Adult HIV-Infected Patients Attending Urban and Rural Care Clinics in Uganda
- Source :
- Open Forum Infectious Diseases
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Liver fibrosis is common among HIV-infected patients. Risk factors vary by location. Understanding this variation may inform prevention strategies. We compared the prevalence and correlates of liver fibrosis among HIV-infected patients attending care clinics in Uganda. Methods This was a cross-sectional study involving 2030 HIV-infected patients attending care clinics in urban and rural Uganda. Liver fibrosis was defined as liver stiffness measurement (LSM) >7.1 KPa. Proportions and correlates of liver fibrosis were assessed and compared using logistic regression stratified by gender and site. Results Prevalence of liver fibrosis was higher among participants in the rural clinic (15% vs 11%; P = .017). History of tobacco use (urban P = .022; rural P = .035) and serologic evidence of hepatitis C infection (HCV; urban P = .028; rural P = .03) was associated with liver fibrosis in all men. Elevated liver transaminases (urban P = .002; rural P = .028) and increasing age (urban P = .008; rural P = .052) were risk factors among all women. Tobacco use among women was only a risk factor in those attending the rural clinic (P = .003), and detectable HIV viral load (P = .002) for men in the urban clinic. Conclusions Liver fibrosis is prevalent among HIV-infected persons in Uganda. HIV viral suppression and avoiding tobacco may be strategies to prevent liver fibrosis and cancer risk.
- Subjects :
- medicine.medical_specialty
Liver fibrosis
Logistic regression
Major Articles
Serology
03 medical and health sciences
0302 clinical medicine
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
medicine
030212 general & internal medicine
Risk factor
liver fibrosis
Sub-Saharan Africa
business.industry
ART era
Hepatitis C
medicine.disease
AcademicSubjects/MED00290
Fibroscan
Infectious Diseases
Oncology
HIV/AIDS
030211 gastroenterology & hepatology
Hepatic fibrosis
business
Viral load
Subjects
Details
- ISSN :
- 23288957
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Open Forum Infectious Diseases
- Accession number :
- edsair.doi.dedup.....85192a5f482f153b6a140aaffc7e1d8e
- Full Text :
- https://doi.org/10.1093/ofid/ofaa483