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Whole-tumour histogram analysis of pharmacokinetic parameters from dynamic contrast-enhanced MRI in resectable oesophageal squamous cell carcinoma can predict T-stage and regional lymph node metastasis
- Source :
- European journal of radiology. 112
- Publication Year :
- 2018
-
Abstract
- Objective To identify whether whole-tumour histogram analysis of pharmacokinetic parameters from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could predict T-stage and regional lymph node metastasis (LNM) of resectable oesophageal squamous cell carcinoma (SCC). Materials and methods Forty-two consecutive patients with confirmed oesophageal SCC underwent thoracic DCE-MRI. Histogram metrics (median, mean, standard deviation [SD], skewness, kurtosis and entropy) of whole-tumour pharmacokinetic parameters including endothelial transfer constant (Ktrans), reflux rate (Kep) and fractional extravascular extracellular space volume (Ve) were generated by the Omni-Kinetics software. Histogram datasets were interpreted using the Mann-Whitney U test and receiver operating characteristic (ROC) statistical analyses. Results The Mann-Whitney U tests revealed that the median, mean and SD of Ktrans, the SD and entropy of Kep, and the median, mean and entropy of Ve of T1-2 stage oesophageal SCC were lower when compared with T3 stage (all Ps Conclusion Whole-tumour histogram analysis of pharmacokinetic parameters of oesophageal SCC on DCE-MRI could be used to predict T-stage and regional LNM.
- Subjects :
- Male
Esophageal Neoplasms
Contrast Media
Perfusion scanning
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Radiology, Nuclear Medicine and imaging
Esophagus
Aged
Neoplasm Staging
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Magnetic resonance imaging
General Medicine
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
030220 oncology & carcinogenesis
Lymphatic Metastasis
Dynamic contrast-enhanced MRI
Kurtosis
Mann–Whitney U test
T-stage
Female
Esophageal Squamous Cell Carcinoma
Lymph Nodes
business
Nuclear medicine
Epidemiologic Methods
Subjects
Details
- ISSN :
- 18727727
- Volume :
- 112
- Database :
- OpenAIRE
- Journal :
- European journal of radiology
- Accession number :
- edsair.doi.dedup.....851b22c79ebf91c3185d2c8834892dce