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Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes

Authors :
Manal F, Abdelmalek
Mariana, Lazo
Alena, Horska
Susanne, Bonekamp
Edward W, Lipkin
Ashok, Balasubramanyam
John P, Bantle
Richard J, Johnson
Anna Mae, Diehl
Jeanne M, Clark
Steven, Solga
Source :
Hepatology. 56:952-960
Publication Year :
2012
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2012.

Abstract

Fructose consumption predicts increased hepatic fibrosis in those with nonalcoholic fatty liver disease (NAFLD). Because of its ability to lower hepatic adenosine triphosphate (ATP) levels, habitual fructose consumption could result in more hepatic ATP depletion and impaired ATP recovery. The degree of ATP depletion after an intravenous (IV) fructose challenge test in low- versus high-fructose consumers was assessed. We evaluated diabetic adults enrolled in the Action for Health in Diabetes Fatty Liver Ancillary Study (n = 244) for whom dietary fructose consumption estimated by a 130-item food frequency questionnaire and hepatic ATP measured by phosphorus magnetic resonance spectroscopy and uric acid (UA) levels were performed (n = 105). In a subset of participants (n = 25), an IV fructose challenge was utilized to assess change in hepatic ATP content. The relationships between dietary fructose, UA, and hepatic ATP depletion at baseline and after IV fructose challenge were evaluated in low- (

Details

ISSN :
02709139
Volume :
56
Database :
OpenAIRE
Journal :
Hepatology
Accession number :
edsair.doi.dedup.....851e9045313a12cf992735bd2cbaf769
Full Text :
https://doi.org/10.1002/hep.25741