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Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder

Authors :
Jian-Bao Wang
Li-Jun Zheng
Qing-Jiu Cao
Yu-Feng Wang
Li Sun
Yu-Feng Zang
Hang Zhang
Source :
Frontiers in Neuroscience, Frontiers in Neuroscience, Vol 11 (2017)
Publication Year :
2017
Publisher :
Frontiers Media S.A., 2017.

Abstract

Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The present study analyzed three voxel-wise whole-brain metrics, i.e., amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) based on the pooled dataset as well as individual cohort of ADHD-200. In addition to the conventional frequency band of 0.01–0.08 Hz, sub-frequency bands of 0–0.01, 0.01–0.027, 0.027–0.073, 0.073–0.198, and 0.198–0.25 Hz, were assessed. While the pooled dataset showed abnormal activity in some brain regions, e.g., the bilateral sensorimotor cortices, bilateral cerebellum, and the bilateral lingual gyrus, these results were highly inconsistent across cohorts, even across the three cohorts from the same research center. The standardized effect size was rather small. These findings suggested a high heterogeneity of spontaneous brain activity in ADHD. Future studies based on multi-site large-sample dataset should be performed on pooled data and single cohort data, respectively and the effect size must be shown.

Details

Language :
English
ISSN :
1662453X
Volume :
11
Database :
OpenAIRE
Journal :
Frontiers in Neuroscience
Accession number :
edsair.doi.dedup.....8549f01c347dfb36b042cad9325d59e1
Full Text :
https://doi.org/10.3389/fnins.2017.00320