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Inconsistency in Abnormal Brain Activity across Cohorts of ADHD-200 in Children with Attention Deficit Hyperactivity Disorder
- Source :
- Frontiers in Neuroscience, Frontiers in Neuroscience, Vol 11 (2017)
- Publication Year :
- 2017
- Publisher :
- Frontiers Media S.A., 2017.
-
Abstract
- Many papers have shown results from the multi-site dataset of resting-state fMRI (rs-fMRI) in attention deficit hyperactivity disorder (ADHD), a data-sharing project named ADHD-200. However, few studies have illustrated that to what extent the pooled findings were consistent across cohorts. The present study analyzed three voxel-wise whole-brain metrics, i.e., amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC) based on the pooled dataset as well as individual cohort of ADHD-200. In addition to the conventional frequency band of 0.01–0.08 Hz, sub-frequency bands of 0–0.01, 0.01–0.027, 0.027–0.073, 0.073–0.198, and 0.198–0.25 Hz, were assessed. While the pooled dataset showed abnormal activity in some brain regions, e.g., the bilateral sensorimotor cortices, bilateral cerebellum, and the bilateral lingual gyrus, these results were highly inconsistent across cohorts, even across the three cohorts from the same research center. The standardized effect size was rather small. These findings suggested a high heterogeneity of spontaneous brain activity in ADHD. Future studies based on multi-site large-sample dataset should be performed on pooled data and single cohort data, respectively and the effect size must be shown.
- Subjects :
- medicine.medical_specialty
multi-site dataset
Future studies
Brain activity and meditation
resting state fMRI
Audiology
050105 experimental psychology
Developmental psychology
lcsh:RC321-571
Lingual gyrus
03 medical and health sciences
0302 clinical medicine
medicine
Attention deficit hyperactivity disorder
0501 psychology and cognitive sciences
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Original Research
Resting state fMRI
Sensorimotor Cortices
General Neuroscience
Homogeneity (statistics)
05 social sciences
medicine.disease
attention deficit hyperactivity disorder
Cohort
ADHD-200
voxel-wise whole-brain analysis
Psychology
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 1662453X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Neuroscience
- Accession number :
- edsair.doi.dedup.....8549f01c347dfb36b042cad9325d59e1
- Full Text :
- https://doi.org/10.3389/fnins.2017.00320