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microRNA-184 functions as tumor suppressor in renal cell carcinoma
- Source :
- Experimental and Therapeutic Medicine
- Publication Year :
- 2015
- Publisher :
- Spandidos Publications, 2015.
-
Abstract
- microRNAs (miRNAs) are evolutionarily conserved, endogenous, small, noncoding RNA molecules of approximately 22 nucleotides in length that function as post-transcriptional gene regulators. Their aberrant expression may be involved in human diseases, including cancer. Although miRNA-184 (miR-184) has been reported in other tumors, its function in renal cell carcinoma (RCC) is still unknown. The aim of the present study was to investigate the role of miR-184 in RCC. The impacts of miR-184 on cell migration, proliferation and apoptosis were evaluated using migration scratch, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assay. Our studies revealed that miR-184 mimic significantly inhibits cell migration, suppresses cell proliferation and induces renal cancer cell apoptosis in vitro when compared with the negative control (P
- Subjects :
- renal cell carcinoma
Cancer Research
Pathology
medicine.medical_specialty
microRNA
Oncogene
Cell growth
Cell
Cancer
Cell migration
Articles
General Medicine
Cell cycle
Biology
medicine.disease
medicine.anatomical_structure
miR-184
Immunology and Microbiology (miscellaneous)
Renal cell carcinoma
medicine
Cancer research
Subjects
Details
- ISSN :
- 17921015 and 17920981
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Experimental and Therapeutic Medicine
- Accession number :
- edsair.doi.dedup.....855d582914442651e02276bbb0658146