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Cardiovascular and Renal Effects of Birdseed Associated with Aerobic Exercise in Rats
- Source :
- Medicine and science in sports and exercise. 48(10)
- Publication Year :
- 2016
-
Abstract
- AB Introduction: Phalaris canariensis L. (Pc), known as birdseed, is rich in tryptophan. The aqueous extract of Pc (AEPc) treatment reduced systolic blood pressure (SBP) in spontaneously hypertensive rats (SHR) via mechanisms mediated by the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase (IDO). Hypertension is a risk factor to cardiovascular and renal diseases. Considering that physical exercise improves hypertension and cardiovascular function, the aim of this study was to evaluate whether the benefits of exercise (Ex) would be enhanced by concomitant AEPc treatment (400 mg[middle dot]kg-1[middle dot]d-1 p.o.). Methods: Vascular reactivity was assessed in aorta rings from SHR treated with AEPc for 4 wk. Training intensity was based on maximal lactate steady state obtained during the 2-wk adaptation period in a treadmill running. Then exercised (60 min running, five times per week during 8 wk) or sedentary SHR were untreated or treated with AEPc during 8 wk. SBP was estimated by plethysmograph. Heart mass and body mass were used to obtain the index of cardiac hypertrophy. Glucose tolerance test was evaluated by oral glucose overload, and the mRNA expressions of indoleamine 2,3-dioxygenase, interleukin 1[beta] (IL-1[beta]), and IL-10 in the kidney were obtained by real time polymerase chain reaction. Results: AEPc induced endothelial-mediated vascular relaxation. AEPc or Ex alone reduced SBP, the index of cardiac hypertrophy and ventricular fibrosis, improved glucose metabolism, and attenuated proteinuria and the renal expression of the proinflammatory IL-1[beta] with an overexpression in the anti-inflammatory IL-10. AEPc potentiated the benefits of the Ex on the cardiovascular system, metabolic parameters, and renal inflammation. Conclusion: Birdseed reduced cardiovascular risk related to hypertension and had positive effects when associated to physical exercise. (C) 2016 American College of Sports Medicine
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Interleukin-1beta
Physical Therapy, Sports Therapy and Rehabilitation
Physical exercise
Blood Pressure
Kidney
03 medical and health sciences
Internal medicine
medicine.artery
Physical Conditioning, Animal
Rats, Inbred SHR
medicine
Plethysmograph
Aerobic exercise
Animals
Indoleamine-Pyrrole 2,3,-Dioxygenase
Orthopedics and Sports Medicine
Phalaris
Glucose tolerance test
Aorta
medicine.diagnostic_test
business.industry
Plant Extracts
Tryptophan
Kidney metabolism
030104 developmental biology
medicine.anatomical_structure
Endocrinology
Blood pressure
business
Subjects
Details
- ISSN :
- 15300315
- Volume :
- 48
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Medicine and science in sports and exercise
- Accession number :
- edsair.doi.dedup.....855df11568b5c54680a6d157b2c0aff3