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PM2.5 Associated With Gray Matter Atrophy Reflecting Increased Alzheimer Risk in Older Women
- Source :
- Neurology
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- ObjectiveTo examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters MethodsAD pattern similarity (AD-PS) scores, developed by supervised machine learning and validated with MRI data from the Alzheimer’s Disease Neuroimaging Initiative, were used to capture high-dimensional gray matter atrophy in brain areas vulnerable to AD (e.g., amygdala, hippocampus, parahippocampal gyrus, thalamus, inferior temporal lobe areas, and midbrain). Using participants' addresses and air monitoring data, we implemented a spatiotemporal model to estimate 3-year average exposure to PM2.5 preceding MRI-1. General linear models were used to examine the association between PM2.5 and AD-PS scores (baseline and 5-year standardized change), accounting for potential confounders and white matter lesion volumes.ResultsFor 1,365 women 77.9 ± 3.7 years of age in 2005 to 2006, there was no association between PM2.5 and baseline AD-PS score in cross-sectional analyses (β = −0.004; 95% confidence interval [CI] −0.019 to 0.011). Longitudinally, each interquartile range increase of PM2.5 (2.82 µg/m3) was associated with increased AD-PS scores during the follow-up, equivalent to a 24% (hazard ratio 1.24, 95% CI 1.14–1.34) increase in AD risk over 5 years (n = 712, age 77.4 ± 3.5 years). This association remained after adjustment for sociodemographics, intracranial volume, lifestyle, clinical characteristics, and white matter lesions and was present with levels below US regulatory standards (3).ConclusionsLate-life exposure to PM2.5 is associated with increased neuroanatomic risk of AD, which may not be explained by available indicators of cerebrovascular damage.
- Subjects :
- medicine.medical_specialty
business.industry
Women's Health Initiative
Hazard ratio
010501 environmental sciences
medicine.disease
01 natural sciences
Article
Hyperintensity
Confidence interval
Temporal lobe
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Atrophy
Interquartile range
Internal medicine
medicine
Cardiology
Neurology (clinical)
business
030217 neurology & neurosurgery
Parahippocampal gyrus
0105 earth and related environmental sciences
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....858e472a531b6e40cad1cf8bc2ecd70a