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Two weeks of remote ischaemic preconditioning alters sympathovagal balance in healthy humans
- Source :
- Experimental Physiology. 105:1500-1506
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- NEW FINDINGS What is the central question of this study? Delayed cardiovascular responses occur following a single bout of remote ischaemic preconditioning (RIPC). Is heart rate variability (HRV), a surrogate marker of cardiac vagal control, able to detect a delayed effect after a single bout of RIPC? Do repeated bouts of RIPC further alter HRV? What is the main finding and its importance? Indices of HRV indicated a shift in sympathovagal balance toward greater parasympathetic activity following 2 weeks of RIPC but not after a single bout of RIPC. Thus, repeated bouts of RIPC were necessary to elicit changes in autonomic function. ABSTRACT Remote ischaemic preconditioning (RIPC), induced by brief periods of ischaemia followed by reperfusion, protects against ischaemia-reperfusion injury and improves microvascular function. However, the effect of RIPC on autonomic function remains unclear. We hypothesized that RIPC, administered as a single bout or repeated over a 2-week period, will increase markers of cardiac vagal control measured by heart rate variability (HRV). Thirty-two young adults performed a single bout (n = 13), repeated bouts (n = 11), or served as a time control (n = 8). RIPC sessions consisted of four repetitions of 5 min unilateral brachial artery occlusion interspersed by 5 min of reperfusion. For the single bout protocol, resting lead II electrocardiogram (ECG) was collected before and 24, 48, 72 and 168 h post-RIPC. The repeated bout protocol consisted of three 4-day periods of RIPC training, each interspersed by a 1-day break. Similar to time controls, ECG was collected before and 24 h after the last RIPC bout. HRV was analysed by power spectral density and symbolic dynamics using 350-beat ECG segments. After a single bout of RIPC, no changes in HRV were observed at any time point (P > 0.05). After 2 weeks of repeated RIPC, the percentage of zero-variation fragments (baseline = 13.1 ± 1.9%, post-RIPC = 6.9 ± 1.5%, P
- Subjects :
- Adult
Male
Autonomic function
medicine.medical_specialty
Physiology
Ischemia
030204 cardiovascular system & hematology
Brief periods
Young Adult
03 medical and health sciences
0302 clinical medicine
Heart Rate
Parasympathetic Nervous System
Physiology (medical)
Internal medicine
medicine.artery
Occlusion
Humans
Medicine
Heart rate variability
Brachial artery
Ischemic Preconditioning
Balance (ability)
Nutrition and Dietetics
business.industry
Surrogate endpoint
Hemodynamics
Heart
Vagus Nerve
General Medicine
medicine.disease
Cardiology
Female
business
human activities
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 1469445X and 09580670
- Volume :
- 105
- Database :
- OpenAIRE
- Journal :
- Experimental Physiology
- Accession number :
- edsair.doi.dedup.....859cd2e3fbdedcef163a352220709847