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Influence of fluoroquinolones on phagocytosis and killing ofCandida albicansby human polymorphonuclear neutrophils
- Source :
- Medical Mycology. 46:675-684
- Publication Year :
- 2008
- Publisher :
- Oxford University Press (OUP), 2008.
-
Abstract
- Candida albicans infections often occur during or shortly after antibacterial treatment. Phagocytosis by polymorphonuclear neutrophil granulocytes (PMN) is the most important primarily defence mechanism against C. albicans. Certain antibiotics such as some fluoroquinolones (FQ) are known to influence phagocyte functions. Thus, we investigated the influence of older and newer FQ on the phagocytosis and killing of C. albicans by human PMN paying special attention to CD11b expression of these cells as an indicator of the degree of their activation. In order to obtain comprehensive and comparable results we tested 13 FQ over a wide range of concentrations and in a time dependent manner in a standardized approach. When used at therapeutic concentrations, the FQ tested did not influence to a clinically significant degree the phagocytosis or the killing of C. albicans by human PMN and also not their activation. However, at high concentrations those FQ with cyclopropyl-moiety at position N1 showed increase in CD11b expression and diminished phagocytosis and oxidative burst.
- Subjects :
- Adult
Male
Phagocyte
Neutrophils
medicine.drug_class
Phagocytosis
Antibiotics
Microbiology
Young Adult
Candida albicans
medicine
Humans
Respiratory Burst
CD11b Antigen
biology
General Medicine
Middle Aged
biology.organism_classification
Corpus albicans
Anti-Bacterial Agents
Respiratory burst
Infectious Diseases
medicine.anatomical_structure
Gene Expression Regulation
Integrin alpha M
Macrophage-1 antigen
Immunology
biology.protein
Female
Fluoroquinolones
Subjects
Details
- ISSN :
- 14602709 and 13693786
- Volume :
- 46
- Database :
- OpenAIRE
- Journal :
- Medical Mycology
- Accession number :
- edsair.doi.dedup.....85dd985cc0cc2fe1b4fe13e589a59fd7